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Basic Science > Cell Surface Markers/IHC > Flashcards

Cell Surface Markers/IHC Flashcards

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0
Q

Vimentin stains…

A

Mesenchymal cells

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1
Q

Identifies what cell types? Flow, histo, or both?

CD21

A

Mature B cells

Flow and histo

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2
Q

Cytokeratin stains…

A

Epithelial cells

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3
Q

Co-staining with vimentin and cytokeratin can occur in… (Name 5 tumors)

A 
Mesothelioma
Synovial cell sarcoma
Anaplastic sarcoma
Carcinosarcoma
Melanoma
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4
Q

S100 stains…

A

Neural crest origin, including
Adipocytes
Chondrocytes
Melanocytes

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5
Q

GFAP stains…

A

Peripheral nerve sheath tumors

Astrocytes

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6
Q

MelanA stains…

A

Melanoma

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7
Q

Actin stains…

A

Muscle origin cells

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8
Q

Desmin stains…

A

Muscle origin cells

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9
Q

SMA stains

A

Smooth muscle cells

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10
Q

Myoglobin stains…

A

Skeletal and cardiac muscle

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11
Q

Factor XIII stains…

A

Vessel origin cells

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12
Q

Synaptophysin stains…

A

Neuroendocrine origin

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13
Q

Chromogranin stains…

A

Neuroendocrine origin

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14
Q

Thyroglobulin stains…

A

Follicular thyroid cells

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15
Q

Calcitonin stains

A

Parafollicular thyroid cells

16
Q

Identifies what cell types? Flow, histo, or both?

CD3

A

T cells (mature)

Flow and histo

17
Q

Identifies what cell types? Flow, histo, or both?

CD79a

A

B cells (early)

Flow and histo

18
Q

MUM1 stains…

A

Plasma cells

19
Q

Identifies what cell types? Flow, histo, or both?

CD18

A

Histiocytic cells

Flow and histo

20
Q

Uroplakin stains…

A

Prostatic and urothelial

21
Q

cKit stains… (And give CD alias)

A

CD117
Mast cell tumors
GIST

22
Q

Identifies what cell types? Flow, histo, or both?

CD45

A

All leukocytes

Flow only

23
Q

Identifies what cell types? Flow, histo, or both?

CD34

A

Precursor/stem cells

Flow only

24
Q

Identifies what cell types? Flow, histo, or both?

Ig

A

B cell (early and mature)

Flow, maybe histo?

25
Q

Identifies what cell types? Flow, histo, or both?

CD3e

A

T cell (early)

Flow only

26
Q

Identifies what cell types? Flow, histo, or both?

CD3

A

T cell (mature)

Flow and histo

27
Q

Identifies what cell types? Flow, histo, or both?

CD4

A

Neutrophil

Flow and frozen sections

28
Q

Identifies what cell types? Flow, histo, or both?

CD8

A

T cell (mature)

Flow and frozen sections

29
Q

Identifies what cell types? Flow, histo, or both?

CD11c

A

Dendritic cells

Flow and frozen sections

30
Q

Identifies what cell types? Flow, histo, or both?

CD11d

A

LGL

Flow and frozen sections

31
Q

Identifies what cell types? Flow, histo, or both?

CD14

A

Monocytes

Flow only

32
Q

Identifies what cell types? Flow, histo, or both?

CD41

A

Platelets, megakaryocytes

Flow. Histo?

33
Q

Mechanism of action of erythropoietin?

A

Binds to Epo receptor on RBC precursors in bone marrow and prevents apoptosis.

Basic Science (11 decks)

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