Cell signalling cascades Flashcards
1
Q
What are the 2 receptor dependent pathways activated by adrenergic agonist responses ?
A
Alpha adrenoreceptor
Beta adrenoreceptor
2
Q
What does adrenalin activate ?
A
The phosphorylase enzyme to induce glycogen breakdown
3
Q
What is the secondmessenger induced by adrenaline?
A
cAMP
4
Q
What does the induction of cAMP lead to ?
A
Activation of phosphorylase
5
Q
What activates Adenylate cyclase ?
A
Activated in response to adrenaline stimulation to generate cAMP
6
Q
What is the structure of Adenylate cyclase ?
A
6 classes (3rd in mammalian)
membrane bound enzymes
N terminus regions C1 and C2 important for reg of Galpha -GTP
10 isoforms
7
Q
What isoforms of adenylate cyclase is inhibited by ca2+?
A
I and VI
