cell signaling pt 3

Question 1

REceptor coupling directly to TF

Answer 1

ex: TGF-beta pathway
–>- They function as serine/threonine kinases (as opposed to a tyrosine kinase)
- The TGF-β pathway uses receptors that are heterodimers (that way you can have different combinations)

Question 2

NFKB

Answer 2

• is an important transcription factor in immune cell signaling
• Normally kept in the cytoplasm (inhibited by IκB)
• Once receptor is activated it will activate a kinase that phosphorylate IκB, targeting it for destruction

Question 3

notch signaling

Answer 3

-discovered in drosophila
-found in mammals and important during development (controls cell fate)

-Delta (signal) interacts with Notch (receptor)
- The intracellular domain of Notch can migrate to the nucleus where it will lead to the transcription of genes that control cell fate during development (what each cell will be)