Cell Salvage Flashcards
In what type of surgery is salvaged blood used?
Oncology
What is oncology surgery?
Tumour surgery
What is the main concern caused by transfusion cell salvage?
Systemic dissemination of rein fused tumour cells resulting in disease progression.
What is systemic dissemination?
A disseminated infection is one in which a localized infection spreads (disseminates) from one area of the body to other organ systems.
What was the main problem with transfusional cell salvage in the 1980s?
Auto-transfusion device being used in clinical practise would preserve tumour cells which would later be rein fused into patients and cause them issues.
What is metastasis after the re-transfusion of salvaged blood considered to be caused by now?
Selective growth of highly metastatic cells from the surgical field.
Can CTC cells be found in the patients blood?
They can be detected but it cannot be identified whether these cells will go on to be metastatic or not.
Can we know if identified CTC cells will be metastatic?
No
What is metastasis?
The development of secondary malignant growths at a distance from a primary site of cancer.
In terms of morphology, describe tumour cells
Heterogenous with replicative potential, and antigen and gene expression.
What are CTC cells?
Circulating tumour cells that link a primary tumour and metastasis.
What happens that CTC cells that do not undergo metastasis?
They are arrested in capillary beds or marrow and undergo apoptosis.
Other may remain dormant.
What does CTC count vary depend on?
Type and stage of a tumour.
Why do most CTC cells not go on to cause metastasis?
They fail to complete all steps of the metastatic process or are arrested in the peripheral system and are eliminated by the endoplasmic reticulum.
By what organelle are most CTCs eliminated?
Endoplasmic reticulum
