Cell Proliferation, tissue regeneration and repair Flashcards
What are labile cells defined as?
Continually doubling cells that never enter Go, but continue cycling
What are stable cells defined as?
Cells that enter Go but can reenter when needed
What are permanent cells?
Cells that leave the cell cycle indefinitely, like muscle cells or neurons
Cyclins bind to ____ and activates them
Cyclin dependent kinases
What are the three oncopropteins we need to know?
Ras, Bcr, Abl
Oncoproteins allow passage from ___ into ____
G1 into S phase
What is responsible for applying the “brakes” in the cell cycle?
Tumor suppressor genes
What are the two main tumor suppressor genes?
P53 and RB
What are the three properties of stem cells?
Self renewal, asymmetric replication, and differential potential (depending on the situation)
What produces growth factors?
Leukocytes at the sites of injury
What are the three components of ECM?
Fibrous structural proteins, water hydrated gels, and adhesive glycoproteins
What are integrins?
Protein that interacts with the EC matric to stabilize the position of the cell
What are the four steps of wound healing?
Hemostasis
Inflammation
Proliferation
Maturation and remodeling
What composes granulation tissue in wound healing?
Connective tissue, blood vessels, fibroblasts, keratinocytes, endothelial cells, and inflammatory cells
What do permanent cells get replaced with when they die?
Fibrous scar that is composed of connective tissue
