Cell Membranes and Functions Flashcards
What is the foundation of membrane structures?
Phospholipids
What do phospholipids include?
Glycerol phospholipids and sphingolipids
Where are sphingolipids?
Found throughout the body, primarily in nerve cell membranes. Make 25% of the lipids in the myelin sheet.
What is a myelin sheet?
Thin tissues of fat that insulates nerve tissues and nerve cells.
Helps transport signals quickly through the nervous system.
What is globular proteins?
Rounded, spherical proteins that takes different shape are inserted in the lipid bilayer.
What is the composition of the fluid mosaic model?
Mosaic of proteins floats in or on the fluid bilayer like bonds on a pond.
Integral proteins fitted into phospholipid bilayer. (Embedded Protein)
Channel proteins are also embedded in the phospholipid layer, with a tunnel/tube like appearance. (Transport Protein)
Peripheral are found on the surface but still integrated.
Surface proteins on the surface.
Hydrophilic heads can be seen on the outside, while hydrophobic tails make the interior to create a sandwich.
Carbohydrates like glycolipids are depicted as green strands.
Globular protein are round spheres embedded into the phospholipid layer.
Glycoproteins are attached to globular protein.
Globular protein + glycoprotein = Carbohydrate
Cholesterol within the hydrophilic tails.
Extracellular fluid top side (outside), cytoplasm bottom side (inside cell).
Phospholipid: hydrophilic head + hydrophobic tail
Why is the fluid mosaic model fluid?
The molecules in the model are still able to move around. The proteins are not static. Some level of fluidity.
When carbohydrates attach to the lipid bilayer what is it?
Glycolipids
What are cell surface markers in the phospholipid bilayer?
Glycoproteins and glycolipids
What is the interior protein network?
Peripheral or intracellular membrane proteins?
ex: spectrins
What are transmembrane proteins?
Integral membrane proteins
What are the types of transmembrane proteins
- Carriers
- Channels
- Receptors
What do spectrins do to the cell?
Give shape to cells.
What do clarithins do?
Helps in cell mediated endocytosis
Endocytosis
Mechanism cell uses to bring more molecules into the cell.
What do glycoproteins help with?
Self recognition
What do glycolipids help with?
Tissue recognition
How do we study the cell membrane?
Transmutation electron microscope and scanning electron microscope.
What is lipidomics?
Largescale study of pathways and networks of cellular lipids. Grouped by number of molecules and biological functions of the different lipids.
How many lipids are there in cells?
1000 distinct lipids
How are lipids divided into three classes?
Lipids are divided into:
- Glycerol Phospholipids
- Sphingolipids
- Sterols
What is amphipathic?
Polar aspect with a non-polar aspect
ex: Polar head = polar + hydrophilic
Why are polar heads attached to water?
Hydrophilic due to hydrogen bonding of water itself as polar heads hold the layers together.
Why are bilayers fluid?
Individual phospholipids that make up the bilayer are not static, unanchored proteins move through membrane.
What temperate makes membrane more fluid?
Warm temperatures > Cold
What is the effect of fats on the membrane fluidity?
Saturated fats make the membrane less fluid than unsaturated fatty acids.
What is the lipid composition of ER, Golgi stack, and plasma membranes?
Each structure has different lipid compositions.
ex: ER is more fluid than plasma membrane as more unsaturated fats result in a lack of tight packing.
What does cholesterol do to the plasma membrane?
Introduces fluidity
What the functions of membrane proteins (plasma membrane)?
- Transporters
- Enzymes
- Cell-surface receptors
- Cell surface identity markers
- Cell to cell adhesion proteins
- Attachments to cytoskeleton
- Affect membrane structure
Transporter protein functions
Selectively allow certain molecules to pass through the bilayer through its channel.
Enzyme protein functions
When there is a molecule that cell needs, converts into products to undergo a reaction inside the cell.