Cell Membranes Flashcards
Describe the fluid mosaic model of membranes.
Fluid: phospholipid bilayer in which individual phospholipids can move giving the membrane a flexible shape.
Mosaic: extrinsic and intrinsic proteins of different sizes are embedded
Explain the role of cholesterol and glycolipids in membranes.
Steroid molecule ( cholesterol) - connects phospholipids and reduces fluidity to make bilayer more stable
Glycolipids - cell signalling and cell recognition
Explain the function of extrinsic proteins in membranes.
-Binding sites/ receptors e.g for hormones and drugs
-Antigens (glycoproteins)
-Bind cells together
-Involved in cell signalling
Explain the functions of intrinsic transmembrane proteins in membranes.
-Channel proteins
(facilitated diffusion)
-Carrier proteins (facilitated diffusion/ active transport)
Explain the functions of membranes within cells.
- Selectively permeable to regulate passage of molecules into/ out of organelles
- Sites of chemical reactions
- Sites of cell communication (cell signalling)
-Compartmentalising
Explain the function of the cell surface membrane
- Isolates cytoplasm from extracellular environment
- Selectively permeable to regulate transport of substances
- Involved in cell signalling/ recognition
- Binding site for hormones/ toxins
Name and explain three factors that effect membrane permeability
Temperature - high temperature denatures membrane proteins/ phospholipid molecules have more kinetic energy and move further apart which increases membrane permeability
Solvents - dissolve the lipids in the membrane creating more space so the membrane becomes more permeable.
Detergents - soap molecules knock the heads off the phospholipids which creates gaps in the membrane increasing permeability.
Define osmosis.
Osmosis is the net movement of water across a semi permeable membrane from an area of higher water potential to an area of lower water potential down a water potential gradient.
What is water potential?
The measure of the ability of water molecules to move freely in solution.
Pure water has the highest water potential.
How does osmosis affect plant and animal cells?
Water moves into the cell:
- plant: protoplast swells = turgid cell
- Animal: lysis (cell bursts)
Water moves out of cell:
- plant: protoplast shrinks = flaccid cell
- Animal: crenation
Define simple diffusion.
Net movement of small, lipid soluble ( able to dissolve in the lipid portion of the membrane) molecules from an area of high concentration to an area of lower concentration down a concentration gradient
Define facilitated diffusion.
Specific channel or carrier proteins with complimentary binding sites transport large or polar molecules/ions down a concentration gradient.
Explain how channel and carrier proteins work?
Channel: hydrophilic channels bind to specific ions = one side of the protein closes and the other opens
Carrier: binds to complimentary molecule = conformational change releases molecule on other side of membrane, in facilitated diffusion: passive process; in active transport: requires energy from ATP hydrolysis.
Define active transport.
Active process: ATP hydrolysis releases a phosphate ion which binds to carrier protein changing its shape.
A specific carrier protein transports molecules/ ions from an area of low concentration to an area of high concentration. (AGAINST A CONCENTRATION GRADIENT)
Define exocytosis and endocytosis.
Endocytosis = A cell can surround a substance with a section of its plasma membrane. The membrane can then pinch off to form a vesicle inside the cell containing the ingested substance.
Exocytosis = Vesicles containing substances which need to be released from the cell e.g. digestive enzymes or lipids pinch off from the sacs of the golgi apparatus and move towards the plasma membrane where they fuse with the plasma membrane and release their contents outside the cell.