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Immunology > Cell-mediated Immunity > Flashcards

Cell-mediated Immunity Flashcards

1
Q

Cd marquer on macrophages

A

CD14

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2
Q

IFN-y activates

A

Classical M1 macrophages and induces B cells to class switch to produce opsonizing IgG antibodies

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3
Q

Il-2

A

Most important growth factor for T cells. Stimulates the proliferation of clines of T cells specific to that antigen.

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4
Q

Stages of CTL killing

A

Attachment
Activation
Exocytosis
Detachment

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5
Q

Valence of IgM

A

10

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6
Q

Affinity

A

Binding strength

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7
Q

Avidity

A

Number of antigen-binding sites available to bind epitopes

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8
Q

Antibody with the highest avidity

A

IgM

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9
Q

X-linked hyper-IgM syndrome

A

Elevated levels of IgM
Deficiency of IgG, IgA and IgE
X-linked recessive

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10
Q

Defect in x-linked hyper-IgM syndrome

A

Defect in the gene encoding CD40 ligand

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11
Q

Function of CD40

A 
Required for the formation of germinal centers
Allows class switching
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12
Q

Most abundant antibody found in blood

A

IgG

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13
Q

IgG subclases

A

IgG1
IgG2
IgG3
IgG4

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14
Q

Most prevalent IgG antobody found in blood

A

IgG1

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15
Q

IgG functions

A

Activates complement
Opsonin
Neutralizes pathogen and toxins
Only antibody able to cross the placenta

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16
Q

Cytokine that drives production of IgA

A

TGF-B

17
Q

Function of IgA

A

Neutralizing antibody

Binds to toxins and pathogens of the mucosa of the digestive, respiratory and urogenital systems

18
Q

Isotypes of IgA

A

IgA1 (bloodstream)

IgA2 (mucosal area)

19
Q

MALT

A

Mucosal-associated lymphoid tissues

20
Q

Function of the secretory component

A

Protects IgA from breakdown

21
Q

Cytokine that allows class switching to IgE

A

IL-4 IL-13

22
Q

Most efficient antibody to activate the complement system

A

IgM

23
Q

Näive B-cell antigen receptor

A

IgM

IgD

24
Q

INF-y

A

Activates classical M1 macrophages to eradicate intracellular pathogens and induces B cells to classs switch to produce opsonizing IgG antibodies that can assist the macrophages with phagocytosis

25
Q

NK CD markers

A

CD16

CD56

26
Q

Effector mechanisms of NK cells

A

perforin, granzymes, cytokines

27
Q

ADCC

A

antibody-dependent cell-mediated cytotoxicity

Immunology (7 decks)

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