Cell markers and path findings

Question 1

Neuroblastoma markers

Answer 1

Catecholamines (homovanillic acid, dopamine, vanillylmandelic acid), ferritin, neuron specific enolase, LDH, GD2

Question 2

Merkel cell markers

Answer 2

Neuron specific enolase, cytokeratins 8, 18, 20

Question 3

Paraganglioma markers

Answer 3

Type I (chief/granular) cells: Neuron specific enolase, chromogranin, synaptophysin.
Type II (sustentacular) cells: S100, Glial Fibrillary Acidic Protein

Question 4

Histology of allergic fungal sinusitis

Answer 4

Charcot Leyden crystals
Necrotic inflammatory cells
Hyphal elements (on surface; if in deep tissue, then indicative of invasive fungal sinusitis)
Eosinophils

Question 5

Calcitonin

Answer 5

MTC

Question 6

CEA

Answer 6

MTC

Question 7

PTC

Answer 7

Markers: Thyroglobulin, HBME-1

Path findings: Papilliform structures with cuboidal cells, orphan Annie nuclei, psammoma bodies, cerebriform nuclei

Question 8

Melanoma

Answer 8

S100, HMB-45, melanin

Question 9

Olfactory neuroblastoma/esthesio path findings

Answer 9

Homer Wright pseudo rosettes (low grade tumors), Flexner Wintersteiner rosettes (higher grade tumors)

Question 10

Olfactory neuroblastoma/esthesiomarkers

Answer 10

Chromogranin, CD 56, synaptophysin, S100, neurofilament

Question 11

Rhabdomyosarcoma markers

Answer 11

Vimentin, myoglobin, myogenin, myoD1, desmin

Question 12

SNUC

Answer 12

Pancytokeratin, low molecular weight keratins and simple keratin

Question 13

Langerhans cell histiocytosis

Answer 13

Birbeck granules, MHC II, CD1a, S100

Question 14

Bartonella henselae path

Answer 14

Positive Warthin-Starry stain

Question 15

Granular cell neoplasm markers

Answer 15

Positive: PAS, NSE, S100, NK1-C3

Question 16

Rhinoscleroma

Answer 16

Foamy histiocytes (Mikulicz cells) with moth eaten appearance, bloated plasma cells (Russell bodies) with birefringent inclusions