Cell joining Flashcards
Types of Tissue
Connective, Muscle tissue, epithelial tissue and nervous tissue
Types of adhesion
Cell-cell and cell to matrix
How does Cell to cell adhesion work
Uses Cell Adhesion molecules
How does cell to matrix adhesion work
Occurs through adhesion receptors to the ECM
What are the different junctions
Gap, Adheren, Desmosomes, and tight
Role of tight junctions
Hold tissue together
Control solute flow and allow polarisation of the plasma membrane
Role of Gap junctions
Allow diffusion, help communication
Role of Adheren Junctions
Hold tissue together
Role of Desmosomes
Hold tissue together
What are the anchoring junctions
Desmosomes and Adherens
What are the anchoring junctions
Desmosomes and Adherens
What are integral proteins
Inside the cells
Integral proteins for Tight junctions
Occludin and Claudin
What are JAMS
Type of CAm junction adhesion molecule
What are adherens made of
5 e-cadherins joined both cis and trans with Ca2+ inbetween them. linked to actin cytoskeletin via intracellular adapters
Adheren intracellular adapters
b- catenin, a-catenin, f-actin, vinculin, p120-catenin
What are desmosomes made of
cadherins. cytoplamic plaque linked to intermediate filaments
What are the cadherins for desmosomes
Desmoglein and desmocollin
What are in the cytoplamis plaque
plakoglobin, desmoplakins and plakophillins
Gap junctions components
Have 2 connexons, innexins and pannexins allow for diect cytoplamic transfer of molecules
What are connexins
They consist of a hemichannel with 6 connexin molecules
Cell-ECM
Focal adhesion and Hemidesmosomes
What are hemidesmosomes
Link cells to ECM, integrins link cytosolic intermediate filaments to the basal lamina via laminin. Epithilial
Hemidesmosomes integral proteins
example plakins
