Cell injury lab

Question 1

Cellular injury may be seen as any of or a
combination of the following patterns

Answer 1

Cellular swelling or lysis
– Cytoplasmic loss of glycogen
– Nuclear pyknosis or lysis
– Cellular fatty change

Question 2

accumulation of triacylglycerol in
hepatocytes

Answer 2

Steatosis

Question 3

Hepatocytes characteristics

Answer 3

• polygonal cells with well
  defined cell borders
• contains one or more nuclei

Question 4

One of the early signs of cellular degeneration in
response to injury

Answer 4

HYDROPIC CHANGE

Question 5

The accumulation of water in the tubular cells is
usually due to

Answer 5

hypoxia

Question 6

Congestive heart failure
Microscopically

Answer 6

Swollen cells are seen with compressed microvasculature

Small clear vacuoles

Question 7

Cellular swelling synonym

Answer 7

hydropic change,
vacuolar degeneration, cellular edema

Question 8

an acute reversible change resulting as a response to
nonlethal injuries

Answer 8

Cellular swelling

Question 9

Conditions that caused fatty change in the liver

Answer 9

Alcoholism

Question 10

Pattern of steatosis in the liver

Answer 10

Microvesicular and macrovesicular

Question 11

retrogressive
condition in which fat droplets are found in the
myocardial sarcoplasm

Answer 11

Fatty degeneration of the heart

Question 12

most common
form and is histologically characterized by
hepatocytes containing a single vacuole of fat
filling up the hepatocyte and displacing the
nucleus to the cell’s periphery.

Answer 12

Macrovesicular steatosis

Question 13

The tubular epithelial cells are distended with cytoplasmic vacuoles while the interstitial
vasculature is compressed

Answer 13

Hydropic change in kidney

Question 15

Characteristics of normal kidney tubules

Answer 15

• Epithelial cells stain evenly pink in
  cytoplasm, with purple, basophilic nuclei
• Apical surfaces are ciliated
• Interstitia not infiltrated with immune cells nor
  congested with proteins

Question 16

Characteristics of Swollen kidney tubules

Answer 16

• Increased eosinophilic staining
• Decreased basophilic staining (RNA)
• Plasma membrane rounding, blebbing, loss of cilia, due to loss of connections with cytoskeletons
• Integrity of tubules degrading, but basement membranes intact
• Nuclei largely intact, slightly narrowed, pyknotic

Question 17

Characteristics of necrotic kidney tubules

Answer 17

• Cellular fragmentation
• Loss and fading of nuclei – Karyolysis
• Burst membranes
• Loss of tissue architecture

Question 18

It is an intracytoplasmic accumulation of water due
to incapacity of the cells to maintain the ionic and
fluid homeostasis

Answer 18

Cellular swelling

Question 19

It is easy to be observed in parenchymal organs:
liver -
Kidney -
Myocardium -

Answer 19

Liver - hepatitis, hypoxia
Kidney - shock
Myocardium - hypoxia, phosphate intoxication

Question 20

Glycogen is seen on what cells

Answer 20

• skeletal muscle
• hepatocytes