Cell Features

Question 1

Blister cells
+ spherocytes

Answer 1

Acute G6PD hemolytic episode

Question 2

Basophilic stippling in RBCs
Hemolysis

Answer 2

Pyrimidine 5’-nucleosidase deficiency
Auto recessive

Question 3

Rh-null disease

Answer 3

Hemolysis
Stomatocytosis

Question 4

Hereditary elliptiocytosis

Answer 4

Pyropoikilocytosis
Bizarre forms and significant poikilocytosis on smear

Auto dominant

Mutations: alpha spectrin, beta spectrin, protein 4.1

Question 5

Unstable hemoglobins

Answer 5

Heinz bodies

(Precipitated oxidized hemoglobin)

Question 6

Bite cells
Blister cells
Heinz bodies

Answer 6

G6PD

Question 7

Howell-Jolly body

Answer 7

DNA-nuclear remnant
Post splenectomy
Asplenia (sickle cell)
Severe hemolytic anemia
Megaloblastic anemia
Congenital dyserythropoietic anemia

Question 8

Rosenthal fibers
“Corkscrew” shaped

Answer 8

Low grade glioma (GFAP+)
Pilocytic astrocytoma

Question 9

Mitoses, vascular proliferation, pseudopalisading necrosis
Tumor pathology

Answer 9

High grade glioma
GFAP+

Question 10

Prominent azurophilic granules in leukocytes
-what lysosomal storage disease?

Answer 10

MPS (Hurler, Hunter, sanfilippo, etc)
Called Alder-Reilly anomaly

Question 11

Hypersegmented bilobed neutrophils on the smear of a healthy child

Answer 11

Pelger-Huet anomaly
Heterozygous mutations in the lamin B receptor gene

(Homozygotes have neutrophils with round unilobed nuclei)

Question 12

Pappenheimer bodies
And basophilic stippling

Answer 12

Can be seen with sideroblastic anemia

Prussian blue staining of BM will reveal ringed sideroblasts

X-linked ringed sideroblastic anemia = ALAS2 gene mutation

Question 13

Where is MPO housed?

Answer 13

Azurophilic granules, or primary granules, within neutrophils