Cell Division Diversity And Organisation Flashcards
What’s a gene mutation
A change in the base sequence of chromosomes
Why do gene mutations occur
Proof reading errors where they mistakenly add or remove a base
What’s a point mutation
Mutations in a single base of DNA or a gain of a single incorrect base
What are base pair deletions
One or more bases being incorrectly deleted from the sequence
What’s a base pair substitution
One or more bases being incorrectly replaced with another base
What is base pair insertion/addition
One or more bases are incorrectly added to the sequence
What are frameshift mutations
Adding/removing a base from a sequence cause the bases to move up/down changing how the gene is read
What are sense and non sense mutations (substitutions)
Affects a sequence of a single codon, the rest of the sequence remains unaffected
What’s a sense mutation
A codon changing but an amino acid is still produced, the amino acid can be the same or different
Why may mutations in the third base of a codon have little effect
The third base of a codon usually doesn’t change the amino acid due to the degenerate nature of codons
What are non sense mutations
A stop codon is coded for producing a shortened protein
Why are non sense mutations so severe
They can result in a dysfunctional proteins which can have adverse effects on cells or be lethal
What are some beneficial aspects of mutations
They can lead to the development of new alleles which can contribute to genetic diversity in a gene pool, and help natural selection
What are mutagenic agents
They increase the rate of gene mutations
What are some examples of mutagenic agents
Ionising radiation (x-rays and gamma rays)
HPV, Formaldehyde and benzene
What are chromosomal mutations
Mutations that occur in entire chromosomes
Why do chromosomal mutations occur
Improper separation of chromosomes during division or improper chromosome recombination
What can breakage of chromosomes result in
Deletion, translocation, inversion, duplication
What is deletion
When an entire region of a chromosome is accidentally deleted
What is translocation
When a portion of one chromosome is accidentally switched with a separate non homologous chromosome
What’s inversion
When a portion of a chromosome can break and rejoin into the original chromosome but after inverting itself resulting in a change in sequence
What is duplication
When regions in a chromosome become duplicated