Cell Division Flashcards
How many pairs of chromosomes do we have
23
How many chromosomes in haploid
23
How many chromosomes are in diploid
46
What is a zygote
Fertilised egg cell
DNA + protein =
Histone
DNA + hisstones =
Chromatin
What are chromatids
Short arms
What is the middle of a chromosome called
Centromere
What is the cell cycle
The process of how cells replicate and divide
What are the stages of the cell cycle
G1
S
G2
M- PMAT
What stages are involved with interphase
G1
S
G2
What is involved in the G1 phase
- Growth phase
- Normal metabolic roles
- Checkpoint control mechanism ensures that the cell is ready to enter the S phase
- cells grow in size
- organelles duplicate
- transcription of genes to make RNA occurs
What is involved in the s stages
-DNA replication
-when all chromosomes have been duplicated each one consists of a pair of identical sister chromatids
-rapid phase
-
What is involved in the G2 phase
- Growth and preparations for mitosis
- special chemicals ensure that the cell is ready for mitosis by stimulating proteins that will be involved in making chromosomes condense and in formation of the spindle fibre
What is involved in the m phase
A check point chemical triggers condensation of chromatin
- cell growth stops
- include PMAT
- includes cytokinesis
Describe G zero
A resting place triggered during early G at the restriction point by a checkpoint chemical
When do mutations occur
When cells are not check pointed properly
What are checkpoints
Biological restrictions / traffic point
Where are the two main checkpoints
G1/S
G2/M
What are the purpose of check points
To prevent uncontrolled divisions that would lead to tumours
To detect and repair damage to DNA
Because the cell cycle happens in a specific sequence it ensures that
The cycle cannot be reversed
The DNA is only duplicated once during each cell
What are the 4 stages of mitosis
Prophase
Metaphase
Anaphase
Telophase
Describe prophase
Mitosis
- nucleolus begins to fade
- the centrioles duplicate and move to opposite poles
- the centrioles form spindle fibres
- chromosomes shorten and thicken, becoming visible
- the nuclear envelope begins to disintegrate
Describe metaphase
Mitosis
- chromosomes line up along the equator of the cell
- one chromatid of each pair lies on either sides
- spindle fibres attach to the centromeres
Describe anaphase
Mitosis
- the spindle fibre begin to contact
- sister chromatids are pulled apart to and live to opposite poles of the cell
Describe telophase
Mitosis
- separation of chromatid is complete
- spindle fibres disintegrate
- each chromatid is now a chromosome
- the nuclear envelope reforms around each group of chromosomes
- the cell divides alone the waist via cytokinesis
- both daughter cells formed are identical
What does homologous mean
Mitosis
Chromosomes which are about the same size and contain the same types is genes in same locations. Same alleles
What is meiosis
Type of nuclear division that results in the the formation is cells containing half the number of chromosomes of each patent cell
Formation of gametes
How meiosis produces genetic variation
- crossing over during prophase 1 suffers alleles
- independent assortments of chromosomes in anaphase 1 leads to random distribution of material and paternal chromosomes of each pair
- haploid gametes are produced which can undergo random fusion with gametes derived from another organism of the same species
What are the stages of meiosis
Prophase 1 Metaphase 1 Anaphase 1 Telophase 1 Prophase 2 Metaphase 2 Anaphase 2 Telophase 2
Describe prophase 1
Meiosis
- chromatin condenses and each chromosome super coils
- nuclear envelope breaks down , spindle threads of Tubulin protein form from the centrioles
- chromosomes come together in their homologous pairs
- each member of the pair consists of two chromatids
- crossing over occurs
Describe metaphase 1
Meiosis
- pair of homologous chromosomes, still in their crossed over state attach along the equator of the spindle
- attaches to a spindle thread by its centromere
- homologous pairs are arranged randomly with its members of each pair facing opposite poles of the cell
- the way they line up in the metaphase determines how they will segregate independently when pulled apart during anaphase
Describe anaphase 1
Meiosis
- members of each pair of homologous chromosomes are pulled apart by motor proteins that drag them along the tubulin threads of the spindle
- the centromeres do not divide and each chromosomes consists of two chromatids
- the crossed over area separates from each other , resulting in swapped area of chromosomes and allele shuffling
Describe telophase 1
Meiosis
- two new nuclear envelopes form around each set of chromosomes and the cell divides by cytokinesis
Chromosomes uncoil
-each new nucleus contains half the original number of chromosomes but each chromosomes consists of two chromatids
Describe prophase 2
Meiosis
- if the nuclear envelopes have reformed then they now break down
- chromosomes coil and condense each one consisting of two chromatids
- chromatids of each chromosome are no longer identical due to crossing over in prophase 1
- spindles form
Describe metaphase 2
Meiosis
- chromosomes attach by their new centromere to the equator of the spindle
- chromatids of each chromosome are randomly arranged
- the way that hey are arranged will determine how the chromatids separate during anaphase
Describe anaphase 2
Meiosis
- the centromere divides
- the chromatids of each chromosome are pulled apart by motor proteins that drag them along the tubulin threads of the spindle , towards opposite poles
- the chromatids and therefore randomly segregated
Describe telophase 2
Meiosis
- nuclear envelope form around each of the four haploid Nuclei
- the two cells now divide to give us 4 haploid cells
Define differentiation
Process by which stem cells become specialised into different types of cells
Define epithelial cells
Cells that constitute lining tissues
What are erythrocytes
Red blood cells
What are neutrophil
Type of white blood cells that is phagocytic