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CMB 1 > cell division > Flashcards

cell division Flashcards

1
Q

prophase

A

condensation
centromeres
spindle

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2
Q

prometaphase

A

envelope

attachment

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3
Q

metaphase

A

equator - most condensed

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4
Q

anaphase

A

separation - poles

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5
Q

telophase

A

decondense

envelope

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6
Q

role of cytoskeleton

A

spindle = microtubules

contractile ring = actin

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7
Q

metaphase checks

A

are chromosomes aligned

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8
Q

g1 check

A

are there GFs about

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9
Q

g2 check

A

is dna replicated properly/any damage

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10
Q

cyclins in yeast

A

S&M

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11
Q

cyclin at g1

A

cyclin d

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12
Q

cyclin that triggers s phase

A

cyclin e

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13
Q

cyclin that triggers g2

A

a

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14
Q

cyclin that trigges mitosis

A

cyclin b

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15
Q

what terminates cdk activity

A

cyclin degradation

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16
Q

what does the kinetochore do

A

attach centromere to spindle

17
Q

cdk for cyclin b

A

1

18
Q

cdk for cyclin e and a

A

cdk2

19
Q

cdk for cyclin 2

A

cdk4

20
Q

how does g1 start

A

expression of cyclin do

21
Q

what happens in g1 after expression of cyclin d

A

cdk4 activation

22
Q

what’s caused by activation of cdk 4

A

release, activation of e2f from pRB

23
Q

what does active E2F do

A

cause transcription of the S phase gene

24
Q

why does arrest at g1 occur if there’s DNA damage

A

damage causes p53 phosphorylation
active p53 binds to p21 promoter region
p21 inhibits g1/s-cdk and s-cdk complex by binding

CMB 1 (3 decks)

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