cell division Flashcards
prophase
condensation
centromeres
spindle
prometaphase
envelope
attachment
metaphase
equator - most condensed
anaphase
separation - poles
telophase
decondense
envelope
role of cytoskeleton
spindle = microtubules
contractile ring = actin
metaphase checks
are chromosomes aligned
g1 check
are there GFs about
g2 check
is dna replicated properly/any damage
cyclins in yeast
S&M
cyclin at g1
cyclin d
cyclin that triggers s phase
cyclin e
cyclin that triggers g2
a
cyclin that trigges mitosis
cyclin b
what terminates cdk activity
cyclin degradation
what does the kinetochore do
attach centromere to spindle
cdk for cyclin b
1
cdk for cyclin e and a
cdk2
cdk for cyclin 2
cdk4
how does g1 start
expression of cyclin do
what happens in g1 after expression of cyclin d
cdk4 activation
what’s caused by activation of cdk 4
release, activation of e2f from pRB
what does active E2F do
cause transcription of the S phase gene
why does arrest at g1 occur if there’s DNA damage
damage causes p53 phosphorylation
active p53 binds to p21 promoter region
p21 inhibits g1/s-cdk and s-cdk complex by binding
