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Cell+Mol Pathology > cell cycle fundamental processes > Flashcards

cell cycle fundamental processes Flashcards

1
Q

G1

A

Cells only grow

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2
Q

G0

A

checkpoint

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3
Q

S phase

A

DNA synthesis + growth (more organelles made)

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4
Q

G2

A

checks made, before committing to mitosis

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5
Q

-‘plasia’ meaning

A

growth/proliferation

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6
Q

necrosis is …

A

unprogrammed cell death

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7
Q

How is metaphase an important checkpoint

A
  • sensors for tension across centromere
  • if tension is not equal
  • signals to nucleus
  • prevents uneven pulling
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8
Q

M cell + any other cell ….

A

dominant biochemical signal from mitotic cell signals other cell to divide

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9
Q

G1 cell + S phase cell

A

S phase signal is dominant

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10
Q

S phase cell + G2 cell

A

= G2 delay
cell doesn’t progress unless all all aDNA is synthesised

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11
Q

alternation (define + proteins involved)

A
  • Cell cycle events occur in the right order
  • cyclins and cdks
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12
Q

completion

A

one process must finish before the next one starts

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13
Q

cyclin binding cdk =

A

phosphorylation of cdk (by CAK)

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14
Q

cdks inhibited by phophphorylation (where and by what kinases)

A

at T14 and Y15
by wee1 and mik1

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15
Q

a promoter of mitosis

A

Cdc25 (phosphatase) - takes phosphate off of Cdks (and activates them?)

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16
Q

cdkis

A

cyclin dependant kinase inhibitors

17
Q

CDKN2 (INK4)

A

bind and inhibit cdk4/6

18
Q

CDKN1

A

inhibit E- and A- dependant cyclins

19
Q

4 stages of cell cycle and the cyclin/cdk involved

A
  1. G1 - cyclin D, cdk4/6
  2. S - cyclin E, cdk2
  3. G2 - cyclin A, cdk2
  4. M - cyclin B, cdk1
20
Q

cyclin c + cdk1 complex

A

phosphorylates APC

21
Q

degradation of cyclin B (when tagged by Ub)

A

trigger for anaphase

22
Q

anaphase checkpoint prevents …

A

aberrant mitosis (not proper chromosome separation)

23
Q

growth factor signalling is required for …

A

passage through G1 restriction (R) checkpoint

24
Q

G1 checkpoint -

A

draw it out

25
Q

Rb is a …

A

transcription repressor

26
Q

p27kip1 inhibits …

A

the cyclin E + cdk2 complex

Cell+Mol Pathology (8 decks)

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