Cell Cycle, Communication, Signal Transduction Flashcards
Why do cells divide
Wound healing and organ maintenance
How do cells divide
Cell growth and chromosome replication
Chromosome segregation
Cell division
Mitosis
Prophase, prometaphase, metaphase, anaphase, telophase
Prophase
Cytoskeletal structure is checked if it is ready for cell division
Prometaphase
Chromosomes are accessible for microtubules (nuclear envelope is fragmented)
Metaphase
All condensed chromosomes are aligned
Anaphase
Chromosomes are moving to the side
Telophase
Reformation of nulcear envelope, subdivide cytoplasm
Cytokinesis
2 daughter cells are separated
G1 phase
Cell growth, new organelles, transcription and translation
G0
Cell in rest
S-phase
DNA synthesis, duplication of chromosomes
G2-phase
Cell growth, cpndensate chromosomes, check internal/external factors
Interphase and M-phase
Interphase: G1, G2, S, G2
M-phase: Mitosis and cytokinesis
Cell cycle check points
Enter cell cycle and proceed to S-phase (environment favorable)
G2/M checkpoint (environment favorable)
Trigger anaphase and proceed to cytokinesis (are all chromosomes attached to the spindle)
Checkpoints regulated by cyclins and cyclin-dependent kinases
Cyclin activity
is ended up by ubiquitination and degradation of the cyclin
Survivin
critical to form the microtubule spindles
centrioles
precedes spindle formation, dubplicated during S-phase and migrate to opposite sides of the nucleus ( under control of M-cdk)
Anaphase A and B
A: shortening of kinetochore microtubules
B: Sliding force is generated between interpolar
Cytokinesis is triggered by
Dephosphorylation of Cdks and cyclin breakdown by APC/C ubiquitination
Midbody
Final contact between 2 daughter cells