Cell Cycle and Mitosis Flashcards
What is the purpose of mitosis?
to enable cells t generate new, genetically identical cells for growth and replacement
How many chromosomes do humans have?
46 chromosomes, 23 pairs
Haploid and Diploid
Haploid (n): 1 set of chromosomes, 23 total
Diploid (2n): 2 sets of chromosomes, 46 total
Centromeres
sequence of DNA; cohesion proteins bind each centromere of each sister chromatid
Kineticore
where microtubules bind on a chromosome
Interphase
G1: cell size and protein content increase, cell size doubles
S: when DNA replicates
G2: all organelles duplicate, synthesize microtubules, cell becomes organized
The spindle
composed of proteins (most microtubules), spindle fibers connect at each pole to the centriole
Prophase
condensed chromosomes, nucleus intact, centrosomes migrate to polls forming spindle
Prometaphase
nuclear envelope is gone, microtubules attach, chromosomes begin to move to center of cell
Metaphase
alignment of chromosomes along metaphase plate
Anaphase
starts when centromeres split, cohesion proteins are removed from all chromosomes, sister chromatids are pulled to opposite poles
Telophase
spindle disassembles, nuclear envelopes form, nucleolus reappears and chromosomes begin to uncoil
Cytokinesis
cells split into equal halves (via cleavage furrow), actin polymerizes forming an actin contractile ring to split cells