Cell Cycle and DNA Repair (Becker) Flashcards
Describe the Cell Cycle: Interphase, G1, S, G2, Mitosis, Cytokines, G0
Describe the stages in Mitosis?
What are mutations, how do they happen?
What is aneuploidy? What happens during mitosis
How does the cell respond to UV light exposure? P53, melanin, ROI?
Protein changes in Expression?
2 types of DNA damage, what is depurination and dypyrimidination?
4 types of DNA damage, 3 types of repair
What is base excision repair? What is nucleotide excision repair? What actually detects the errors in the first place for these two? What disease is associated in abnormal processing for the detectors?
What is mismatch repair? How is it fixed?
What are the two checkpoints in the cell cycle? What do they check?
What are the steps of UV-induced cell cycle arrest MUST KNOW and functions of P53 and P21.
When is p53 most needed?
G1 to S phase
What is non homologous recombination and homologous recombination? What are they used for?
Non-homologous brings together towo ends of chromosomes present, may not have same sequence at end.
Homologous - uses chromosome as template.
Two types of translocations?
Two types of translocations?
4 protein structures
4 kinds of point mutations?
4 Kinds of point mutations (again)
What is the goal of meiosis (2) and what events take place for this to happen?
Major events in Meiosis 1 and Meiosis 2?
Steps of Meiosis 1?
Steps of Meiosis 2?
Compare mitosis and meiosis: DNA replication, number of divisions, pairing of homologous chromosomes, sets of chromosomes and daughter cells, role in the body.
What is non-disjunction?
What is anticipation? 3 examples of diseases with this allele abnormal processing
What is Hungtingon’s disease and how is it caused? What two things can lead to the abnormal processing?
*Unequal crossing over events lead to expansion of the triplet!!!!
