Cell Cycle and Cancer Flashcards
Why do cells divide?
Growth of organisms (how we grow)
Repairing damaged cells
Replacing dead cells
Reproduction
How do cells die?
Necrosis: due to unrepairable damage
Apoptosis: programmed cell death (planned)
What happens in the G1 phase?
The cell grows
The cell grows, makes proteins and organelles, takes nutrients, and eliminates waste. DNA is carried in the form of chromatin.
What happens in the synthesis phase (S phase)?
The DNA is replicated
46 single-stranded chromosomes are copied, making 46 double-stranded chromosomes, each made of two sister chromatids held together by centromeres
What is a somatic cell?
All cells in our body except for gametes (egg and sperm cells)
What happens in the G2 phase?
Structures and organelles needed for division are made, centrioles duplicate
What is mitosis?
The division of the genetic material
What happens in prophase?
Chromatin condenses and becomes visible as chromosomes
Nuclear membrane disappears, spindle fibers begin to form
Centrioles move to opposite poles (animal cells only)
What happens in metaphase?
Chromosomes line up in the middle of the cell so each sister chromatid is facing opposite poles
Spindle fibers attach to double-stranded chromosomes at the centromere
What happens in anaphase?
Spindle fibers pull the sister chromatids apart at the centromere
They are now single stranded chromosomes, and they move to the opposite poles
What happens in telophase?
Spindle fiber disappears, nuclear membrane reforms, and chromosomes uncoil into chromatin
Division of genetic material complete
The cell starts to pinch at the center and contains two nuclei
What is cytokinesis?
It starts during telophase but isn’t part of mitosis
Division of cytoplasm and organelles to form two identical daughter cells
What happens during cytokinesis in animal cells?
Cell membrane pinches at the center forming a cleavage furrow that separates into two daughter cells
What happens during cytokinesis in plant cells?
Cell plate forms at the center of the cell, it then becomes the cell wall that separates into two daughter cells
What are cancer cells and how do they form?
A cell that divides uncontrollably, cancer cells develop when there’s a DNA mutation