Cell cycle Flashcards
What is the cell-cycle control system?
A complex network of regulatory proteins that governs the progression through the cell cycle
What are the phases of the cell cycle?
- M
- G1(G0)
- S
- G2
When does chromosome duplication occur?
S phase (S for synthesis, duh)
What stage does cell division occur?
M phase (M for mitosis, duh)
What are the two parts of the M phase?
Mitosis and cytokinesis
In what stage to organelles and proteins grow?
G1and G2
What do the G1, S, and G2 phases make up?
Interphase
If external conditions are unfavourable, what state can a cell enter?
G0
In most eukaryotic, the cell-cycle control system triggers cell-cycle-progression at three major regulatory transitions, or _________.
In most eukaryotic, the cell-cycle control system triggers cell-cycle-progression at three major regulatory transitions, or checkpoints.
What are the three checkpoints?
- Start (restriction point)
- G2/M checkpoint
- metaphase-to-anaphase transition
What kinases are central components of the cell-cycle control system?
Cyclin-dependent kinases (Cdks)
The activities of ____rise and fall as the cell progresses through the cycle, leading to ______changes in the _____________of intracellular proteins that initiate or regulate the major events of the cell cycle.
The activities of Cdks rise and fall as the cell progresses through the cycle, leading to cyclical changes in the phosphorylation of intracellular proteins that initiate or regulate the major events of the cell cycle.
What is the most important Cdk regulator?
Cyclin
Cyclical changes in ______ protein levels result in the cyclic assembly and activation of the _____-___ complexes; this activation in turn triggers cell-cycle events.
Cyclical changes in **cyclin **protein levels result in the cyclic assembly and activation of the cyclin-Cdk complexes; this activation in turn triggers cell-cycle events.
What are the three classes of cyclins eukaryotes require?
- G1/S-cyclins
- S-cyclins
- M-cyclins
