Cell Cycle Flashcards

0
Q

Cyclin CDk complexes assist in the progression for g1 to S

A

Cyclin d and CDk 4 - phos rb which allows e2f to transcribe things ( cyclin e , thymidine kinase, dihydrofolate reductase)
Cyclin e and cdk2 allow it to go to s phase

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1
Q

Tagged with Ubiquitin so it will go to the

A

Proteasome

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2
Q

Cyclin CDk complexed assist in the progression for g2 to m phase

A

Cyclin a cdk2 - mitosis prophase
Cyclin b cdk1 ( activated by CDC 25 ) breaks down the nuclear envelope ( nuclear lamin breakdown) and initiations of mitosis

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3
Q

Role of p21, p27, p57

A

Tumor suppressor genes that bind to and inactivate cyclin- CDk complexes ( p53 controls activation of p21)

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4
Q

Add this to traffic to the lyososome

A

Mannose 6 phosphate by the Golgi

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5
Q

Golgi can modify proteins how

A

N oligosaccharide on asparagine
O oligosaccharide on serene and threonine
Mannose 6 phosphate for lysosome

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