Cell Cycle Flashcards
Cyclin CDk complexes assist in the progression for g1 to S
Cyclin d and CDk 4 - phos rb which allows e2f to transcribe things ( cyclin e , thymidine kinase, dihydrofolate reductase)
Cyclin e and cdk2 allow it to go to s phase
Tagged with Ubiquitin so it will go to the
Proteasome
Cyclin CDk complexed assist in the progression for g2 to m phase
Cyclin a cdk2 - mitosis prophase
Cyclin b cdk1 ( activated by CDC 25 ) breaks down the nuclear envelope ( nuclear lamin breakdown) and initiations of mitosis
Role of p21, p27, p57
Tumor suppressor genes that bind to and inactivate cyclin- CDk complexes ( p53 controls activation of p21)
Add this to traffic to the lyososome
Mannose 6 phosphate by the Golgi
Golgi can modify proteins how
N oligosaccharide on asparagine
O oligosaccharide on serene and threonine
Mannose 6 phosphate for lysosome