Cell Cycle

Question 1

Interphase

Answer 1

G1 (gap) – growth & metabolic activity
S (synthesis) – DNA replication
G2 (gap) – growth & protein synthesis

Question 2

M (mitosis)

Answer 2

nuclear/cell division

Question 3

What controls entry into next phase?

Answer 3

growth factors, survival factors, differentiation factors (help cell transition; G1/S)

Question 4

Without growth factor, cell goes into ___. What is this?

Answer 4

G0; cell still metabolically active but reduced protein synthesis

Question 5

What is this point called where the cell goes into G0/without growth factor?

Answer 5

Restriction point

Question 6

Checkpoints in cell cycle

Answer 6

block cell cycle progression until mistakes are fixed

Question 7

Cell cycle regulators

Answer 7

Cyclin B & Cdk

Question 8

Cyclin activity accumulates during interphase; plummets during mitosis

Answer 8

Cyclins stimulates protein kinase activity = Cdk

Question 9

Cdk1 activity increases during onset of mitosis; rapid decline as cell ends mitosis

Question 10

What is MPF (maturation promoting factor) composed of?

Answer 10

Cyclin B + Cdk subunits

Question 11

What is required for catalytic activity of Cdk1?

Answer 11

Cyclin B

Question 12

G2 –> Mitosis complex