Cell Communication Flashcards
What is the function of glial cells
hep to support, protect and supply neurone w/ nutrients
What are the different types of glial cells
- astrocyte
- microglia
- satellite cells
- oligodendrocyte
- schwann cells
Why are neurons considered “excitable cells”
neurones can be depolarised and repolirised
What are the 4 types of ion channels
- leak channels
- ligand-gated channels
- voltage-gated channels
- metabotropic channels
What is a leak channel
always open channel
How does a ligand-gated channel work
molecule binds to receptor on channel and channel opens
How does a voltage-gated channel work
It is activated by changes in the electrical membrane potential
How does a metabotropic channel work
- molecule binds
- G-protein is activated
- Intracellular messengers modulate ion channels
- Ion channels open
Outline the resting potential
- neuron is not firing
- -70mV
- sodium-potassium pump
- 3 Na+ out
- 2 K+ in
Outline depolarisation
- sodium channels open
- influx of Na+ ions
- more positive membrane potential
Outline repolarisation
- potassium channels open
- efflux of K+ ions
- more negative membrane potential
What is hyperpolarisation
when membrane potential is more negative than resting potential
What is the refractory period
before a neuron can fire again, resting potential needs to be restored
What are Nissl stains
basic dyes that show negatively charged molecules
What is electrophysiology
measures electrical activity of neurons
What is CT
combination of X-rays and computer technology to produce images of inside the body
What is an NMR (MRI)
non-invasive imaging technology that produces 3D detailed anatomical images
What is a fMRI
- evaluates blood flow in the brain called the blood oxygenation level-dependent (BOLD) contrast technique
- brain activity can be picked up by the MRI scanner because of tiny chemical changes in the blood
What are graded potentials
changes in membrane potential which vary depending on the stimulus
What does agonist mean
molecules mimic the action of the internal signal
What does antagonist mean
molecules oppose/block the action of the internal signal