Cell-cell contacts

Question 1

Tight Junction

Answer 1

1. Diffusion Barrier
2. Tissue Intergrity
3. Claudin and Occulin

Question 2

Adherens Junction

Answer 2

1. Organisation of Actin
2. Catenin: link to cytoskeleton
3. Cadherin: cell bridge

Question 3

Gap Junction

Answer 3

1. Cellular Exchange: cytoplasm and small molecules

2. Connexins: small pores (1-2nm)

Question 4

Desmosome

Answer 4

1. Resistance to shear forces

2. Catherin: interacts with intermediate filaments

Question 5

Hemidesmosome

Answer 5

1. Connection to Extracellular Matrix: basal lamina
2. Integrins
3. Cell Signalling

Question 6

Extracellular Matrix

Answer 6

1. Tissue Integrity
2. Cell Migration
3. Secreted protein fibres: collagen, glycoproteins