cell bio test 4 GI II and III BS Flashcards
4 layers of GI tube
mucosa, submucosa, muscularis externa, serosa/adventitia
mucosa of GI tube
epithelium w/basal lamina, lamina propria, muscularis mucosae
lamina propria of mucosa contains what/
connective tissue, glands, blood vessels, lymphatic tissue, lymphatic vessel endowment (segmental differences exist)
how does muscularis mucosae of mucosa increase surface area of GI tube?
contraction of muscle wrinkles the mucosa, this increases the surface area
describe the submucosa of GI tube
glands present in exophagus and duodenum, blood and lymphatics, submucosal or meissner’s plexus
describe muscularis externa
two layers of smooth muscle, contraction=peristalsis, myenteric plexus
What is the submucosal (Meissner’s) plexus
parasympathetic postganglionic neruons and sympathetic postganglionic fibers–regulates glands, blood flow, muscularis mucosae, and is sensory (mechano and chemo)
What is myenteric (Auerbach’s) plexus?
located in muscularis externa, parasympathetic postgangionic neurons and sympathetic postganglionic fibers, controls peristalsis
What is achalasia?
damage to neurons in myenteric plexus causes constriction of LES. Limits passage of food into stomach
what layer of the esophagus has stratified squamous, nonkeratinized epithelium?
mucosa, submucosa, muscularis externa, serosa/adventitia
Where are cardiac esophageal glands found in the esophagus?
lamina propria
where are esophageal glands proper (seromucous) found?
submucosa
What portion of muscularis externa is skeletal?
upper 5%
what portion of muscularis externa is smooth muscle?
lower 50%
adventitia or serosa? Thoracic or abdominal esophagus?
thoracic=adventitia, abdominal=serosa
What is Barrett’s esophagus?
acid reflux causes remodeling of lower esophagus to make metaplastic columnar epithelium with goblet cells. This mucous is to protect esophagus from the acid. Goblet cells appear blue with PAS/acian blue stains. Needs to be monitored for adenocarcinomas!
How will cancer spread in esophagus?
vertically
regions of the stomach
cardia, fundus, body, pylorus
Describe rugae of the stomach
longitudinal folds in undistended stomach, mucosa and submucosa form the folds
describe mucosa of the stomach
surface epithelium-simple columnar, mucous cells; gastric pits; glands empty into gastric pits; gland regions-isthmus, neck and fundus; lymphatic vessels (very few) deep in lamina propria and muscularis mucosae
muscularis externa of stomach
inner oblique layer of smooth muscle-only present in certain regions of the stomach; middle circular layer of smooth muscle-thickened at pylorus
three regions of gastric glands
three regions: isthmus, neck and fundus (base)
cells in isthmus region of gastric gland
surface epithelial cells-secrete mucus, parietal (oxyntic) cells-secrete HCL and intrinsic factor, stem cells
cells in neck region of gastric gland
mucous, more parietal and less chief cells, some enteroendocrine