cell and nuclear division Flashcards
interphase
-cell growth and synthesis of cell materials
-DNA replication
nuclear division
-nucleus divides to form two nuclei
cytokinesis
-cell surface membrane invaginates towards cell equator
-the cleavage furrow deepens until the parent cell is pinched into two, producing two daughter cells
-cytoplasm divides evenly to form two daughter cells
chromatin structure
-is the complex of DNA and proteins
-is the less condensed form of chromosome
chromosome structure
-during nuclear division, DNA condenses into chromosomes
unduplicated chromosome
-consists of a single DNA molecule
duplicated/ replicated chromosome
-consists of two genetically identical DNA molecule
-consists of two genetically identical sister chromatids joined at the centromere, that are formed due to semi-conservative DNA replication during interphase
diploid chromosome number
-two sets of chromosomes, diploid number of chromosomes is 46
-somatic/ non-sex cells
haploid chromosome number
-gametes contain a single set of chromosomes, haploid number of chromosomes is 23
-the 23 chromosomes consists of 22 autosome and a single sex chromosome
-human egg contains 22 autosomes and X chromosome
-human sperm contains 22 autosomes and an X or a Y chromosome
homologous chromosomes
-in a diploid cell, each type of chromosome exists as a pair of homologous chromosomes, each chromosome is a homolog
-may have different alleles, alleles are alternative forms of the same gene with a slight different nucleotide sequence
homologous chromosomes have
-the same length
-the same position of centromeres
-the same genes as the same loci
mitosis prophase
-longest phase in mitosis
-DNA coils and condenses into duplicated chromosomes with two genetically identical sister chromatids joined at their centromeres
-centrosomes organise microtubules into spindle fibres and migrate to opposite poles of the cell by lengthening of spindle fibres
-nucleolus seems to disappear
-nuclear envelope fragments
mitosis metaphase
-spindle fibres attach to kinetic horse proteins at the centromeres, becoming kinetochore microtubules
-centromeres of chromosomes are aligned along the cell equator
mitosis anaphase
-shortest phase in mitosis
-centromeres separate and two genetically identical sister chromatids separate, thus becoming two unduplicated daughter chromosomes
-daughter chromosomes migrate towards opposite poles of the cell, with the centromere leading the way as kinetochore microtubules shorten
mitosis telophase
-nuclear envelopes reform to form two nuclei
-nucleolus reappears in each nucleus
-chromosomes become decondensed to form back DNA
-spindle fibres break down
significance of mitosis
-each parent cell produces two genetically identical daughter cells with same number and types of chromosomes as parent nucleus
-the genetic stability between generations of cells enables organism growth, tissue repair and asexual reproduction
meiosis prophase I
-DNA coils and condenses into duplicated chromosomes with two genetically identical sister chromatids joined at their centromeres
-centrosomes organise microtubules into spindle fibres and migrate to opposite poles of the cell by lengthening of spindle fibres
-nucleolus seems to disappear
-nuclear envelope fragments
-homologous duplicated chromosomes pair up to form bivalents
meiosis metaphase I
-the bivalents align themselves at the cell equator
-each one homolog is attached to kinetochore microtubules from one of the poles of the cell
meiosis anaphase I
-homologous chromosomes separate
-homologous chromosomes migrate towards opposite poles of the cell, with the centromeres leading the way as kinetochore microtubules shorten
meiosis telophase I
-nuclear envelope reforms, forming two nuclei
-nucleolus reappears in each nucleus
-duplicated chromosomes become decondensed to form back DNA
-spindle fibres break down
meiosis prophase II
-DNA coils and condense into duplicated chromosomes with two genetically identical sister chromatids joined at their centromeres
-nucleolus seems to disappear
-nuclear envelope fragments
meiosis metaphase II
-spindle fibres from centrosome attach to kinetochore proteins at the centromere of each sister chromatid of chromosome, becoming kinetochore microtubules
-centromeres of chromosomes are aligned along the cell equator
meiosis anaphase II
-centromeres separates and two genetically non-identical sister chromatids separate, thus becoming two unduplicated daughter chromosomes
-daughter chromosomes migrate toward opposite poles of the cell, with the centromere leading the way as kinetochore microtubules shorten
meiosis telophase II
-nuclear envelopes reform to form two nuclei
-nucleolus reappears in each nucleus
-unduplicated chromosomes become decondensed to form back DNA
-spindle fibres break down
significance of meiosis
-ensures maintenance of chromosomal number in offspring and prevent doubling of chromosomal numbers during fertilisation
-generates genetic variation in offspring by producing recombinant gametes by crossing over between non-sister chromatids of homologous chromosomes and independent assortment of homologous chromosomes
process that contribute to genetic variation arising from sexual reproduction
-crossing over between non-sister chromatids of homologous chromosomes
-independent assortment of homologous chromosomes
-random fertilisation of gametes
crossing over
-occurs between non-sister chromatids of homologous chromosomes resulting in chiasmata formation
-during prophase I of meiosis
-results in the exchange corresponding DNA segment of chromatids, thus separating linked genes and creating new allelic combinations
independent assortment of homologous chromosomes
-random orientation of pars of homologous chromosomes along the cell equator
-during metaphase I
-in humans the number of possible chromosomal combination is 2 power 23 =8388608
random fertilisation of gametes
-during fertilisation, genetic material from two different individuals is combined by random fusion of gametes’ nuclei
-in humans, the number of possible combinations is (2 power 23) (2 power 23)
non-disjunction
-pair or pairs of homologous chromosomes failed to separate during anaphase I
-sister chromatids failed to separate during anaphase II
-results in extra chromosome/ lacks a chromosome
-eg. down syndrome