Celiac Disease Flashcards
Celiac disease is also called what?
Gluten sensitivity or enteropathy
What is celiac disease?
Malabsorption disorder caused my immunologic response to gluten
Gluten is a storage protein found in what?
Wheat, barley, rye
The problem with celiac disease is with what component of gluten?
Gliadin
What kind of damage occurs with celiac disease?
Diffuse damage to proximal SI mucosa and villous atrophy
Has the incidence of celiac disease increased or decreased in the last 50 years?
Increased
Largest affected population with celiac disease?
Whites of Northern European ancestry but also present in worldwide populations
Etiologies of celiac disease?
Genetics, environmental gluten, overexposure, incidence in 1st degree relatives: 10%
What is steatorrhea?
Fat in the stool
How long does it take to diagnose celiac disease?
Delayed dx, s/s present usually 10 yes before dx
How fast is the dx of celiac disease in infancy if failure to thrive?
Usually rapid testing/dx
Signs and symptoms occur at what age for celiac disease?
Any age, infancy through 8th decade of life (10-40 y/o MC**)
How many patients are asymptomatic at initial finding of celiac disease?
40%
(Starting to see a shift toward asymptomatic pts)
Classic symptoms of celiac disease?
Diarrhea, steatorrhea, weight loss, weakness, abdominal distention, glossitis
In children: failure to thrive, stunted growth, delayed puberty
Atypical symptoms of celiac disease?
Fatigue, depression, delayed puberty, amenorrhea, infertility, peripheral neuropathy
Celiac disease symptoms may be related to which specific nutrient deficiencies ?
Iron, Vit K, Vit A, Vit B12
Iron deficiency signs w celiac?
Fatigue, pallor (look for pallor inside of mouth as well)
Vit K deficiency symptoms in celiac?
Easy bruising