Celiac Diseas

Question 1

Serologic testing :

Answer 1

اول شي بنسويه

• anti-tissue transglutaminase Antibodies.
• anti- deamidated gliadin peptide antibodies.
• IGA anti- endomysial .
—

Question 2

Duodenal biopsy

Answer 2

• flattening of the mucosa with loss of villi • hyperplasia of crypts
• chronic iflammatory infiltration of the lamina propria with lymphocytes.
• the most changes are Seen in the duodenum and proximal jejunum.

Question 3

Clinical presentation of Celiac disease ?

Answer 3

_

hypersensitivity to gluten, a protein
found in wheat. (Gliadin)

- 
Children 
• abdominal distension
• diarrhea 
• failure to thrive !!!!

Adults
• chronic diarrhea and bloating.

•• dermatitis herpetiformis !!
Due to lgA deposition at the tips of dermal papillae // resolves with gluten-
free diet.

•• iron deficiency anemia

Question 4

Diagnosis of lgA deficiency ?

Answer 4

igG antibodies are also present and are useful for diagnosis in individuals with igA deficiency
*** increased incidence of lgA deficiency is seen in celiac disease

Question 5

Late Complication of celiac disease in refractory disease despite good dietary control ??

Answer 5

-

• Small bowel carcinoma
• T-cell lymphoma.

Question 6

Tropical sprue

مناطق حاره

Answer 6

-
• Unknown organism.
• Tropical regions 
• arises after infections diarrhea 
• responds  مستجيب to antibiotics// tetracycline.

Associated with :
•megaloblastic anemia due to folate deficiency.
• later B12 deficiency !!