Cefalosporina 2° generación Flashcards

1
Q

Vía de administración

A

Oral y Parenteral

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2
Q

Farmacocinética

A

Oral- Cefaclor y Cefotetan

Parenteral- Cefoxitina y Cefamandol

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3
Q

Distribución y Absorción

A

No penetra SNC

t 1/2- 1 hora

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4
Q

Excreción

A

Renal

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5
Q

Mecanismo de acción

A

Inhibe la transpeptidasa y activa enzimas hidrolíticas

Cefotetan- se metaboliza en hígado a sustancias que inhiben a vitamina k y aldehído deshidrogenasa

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6
Q

Indicaciones terapéuticas

A
Infecciones por:
P. mira bilis
E. coli
Klebsiella
H. influenzae
Neisseria
Streptococcus
Staphylococcus
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7
Q

Contraindicaciones

A

Pacientes con trastornos de coagulación

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8
Q

Clasificación embarazo

A

B

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9
Q

Efectos adversos

A

Enfermedad del suero : Reacción similar a una alergia causada por cefaclor
Reacción disulfiram
Alteraciones de coagulación: trombocitopenia, neutropenia
Síndrome de S-J

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