C.diff

Question 1

1st episode

Answer 1

Non severe: WBC <15 and SCr <133
PO Vancomycin 125mg QDS or
PO metronidazole 400mg TDS

Severe: WBC ≥15 or SCr ≥ 133
PO Vancomycin 125mg QDS

Fulminant: IV metronidazole 500mg q8h or PO vancomycin 500mg QDS or enema vancomycin 500mg QDS

Question 2

Next episode

Answer 2

If initial vancomycin: vancomycin 125mg pulse therapy

If initial metronidazole: IV PO vancomycin 125mg QDS x 10d