CDI

Question 1

First-line for non-severe CDI

Answer 1

PO Fixadomicin 200mg BD x 10d OR
PO Vancomycin 125mg QDS x 10d

Question 2

Second-line/ alternative for non-severe CDI

Answer 2

PO Metronidazole 400mg TDS x 10d

Question 3

First-line for severe CDI

Answer 3

PO Fixadomicin 200mg BD x 10d OR
PO Vancomycin 125mg QDS x 10d

Question 4

First-line for fulminant CDI

Answer 4

IV Metronidazole 500mg TDS + PO Vancomycin 500mg QDS +/- PR Vancomycin 500mg QDS

Treat for 10 days

Question 5

First-line for recurrence of CDI (assuming metronidazole used for initial tx)

Answer 5

PO Vancomycin 125mg QDS x 10d

Question 6

First-line for recurrence of CDI (assuming vancomycin/ fixadomicin used for initial tx)

Answer 6

PO fixadomicin 200mg BD x 10d
OR
PO fixadomicin 200mg BD x 5d, then 5mg EOD x 20d
OR
PO Vancomycin tapered
(125mg QDS x 10-14 d, 125mg BD x 7d, 125mg daily x 7d, 125mg every 2-3 days x 2-8 weeks)