CD4 Effector T cells Flashcards
1
Q
Which cytokines drive the Th1 lineage?
A
IL-12
IFNy
2
Q
Which cytokines drive the Th2 lineage?
A
IL-4
3
Q
Which cytokines drive the Th17 lineage?
A
TGFb
IL-6
4
Q
Which cytokines drive the Tfh lineage?
A
IL-6
5
Q
Which cytokines drive the Tregs lineage?
A
TGFB
IL-12
6
Q
What cytokines do Th1 cells produce?
A
IFN-y
7
Q
What cytokines do Th2 cells produce?
A
IL-4
IL-5
IL-13
8
Q
What cytokines do Th17 cells produce?
A
IL-17
IL-22
9
Q
What cytokines do Tfh cells produce?
A
IL-21
10
Q
What cytokines do Tregs cells produce?
A
TGF-b
IL-10
11
Q
what is the Th1 cells response?
A
classical macrophage activation
- intracellular pathogens
12
Q
what is the Th2 cells response?
A
- alternative macrophage activation
- extracellular parasites
- activation of mast cells, eosinophils and IgE
13
Q
What is the Th17 response?
A
- in response to extracellular bacteria and fungi
- amplify and recruit neutrophils at site of infection
- production of antimicrobial peptides at epithelial barriers to resist microbial invasion
- regeneration of epithelia
