B cells Flashcards
1
Q
what does T cell independent B cell activation produce: (3)
A
- short lived plasma cells
- mainly IgM antibodies
- low affinity Abs
2
Q
what does T cell dependent B cell activation produce: (4)
A
- long lived plasma cells
- isotope switched Abs
- Memory B cells
- high affinity Abs
3
Q
What cytokines are responsible for B cell proliferation?
A
IL-2, IL-4, IL-5, IL-6
4
Q
What cytokines lead to IgG2a and IgG3 class switching?
A
IFNy
5
Q
What cytokines lead to IgG2b and IgA class switching?
A
TGF-b
6
Q
What cytokines lead to IG1 and IGE class switching?
A
IL-4
7
Q
What cytokines lead to IgM antibodies?
A
IL-2, IL-4, IL-5
