CD Molecules Flashcards
CD1
presentation of nonpeptide (lipid and glycolipid) antigens to NKT cells
on dendritic cells
CD3
cell surface expression of and signal transduction by T cell receptors
on T cells
CD4
co-receptor in MHC Class II restricted antigen-induced T cell activation
HIV receptor
on MHC class II T cells
CD8
co-receptor in MHC Class I restricted antigen-induced T cell activation
on MHC class I T cells
CD11a
cell-cell adhesion; binds to ICAM-1 (CD54), ICAM-2 (CD102) and ICAM-3 (CD50)
on Leukocytes
CD11b
phagocytosis of iC3b-coated particles; neutrophil and monocyte adhesion to endothelium (binds CD54/ICAM-1) and extracellular matrix proteins
on APCs: granulocytes, macrophages, dendritic cells, NK cells
CD11c
phagocytosis of iC3b-coated particles; neutrophil and monocyte adhesion to endothelium (binds CD54/ICAM-1) and extracellular matrix proteins
on APCs: granulocytes, macrophages and NK cells
CD14
binds complex of LPS (found on all gram negative bacteria) and LPS-binding protien; displays LPS to TLR4; requred for LPS-induced activation of macrophages and dendritic cells
on DC, macrophages and granulcytes
NEED TO KNOW THAT CD14 RECOGNIZES LPS ON ALL GRAM NEGATIVE BACTERIA WHICH ACTIVATES TLR4 which then upregulates NF-kB
CD18
cell-cell adhesion; binds to ICAM-1 (CD54), ICAM-2 (CD102) and ICAM-3 (CD50); phagocytosis of iC3b-coated particles; neutrophil and monocyte adhesion to endothelium (binds CD54/ICAM-1) and extracellular matrix proteins
on leukocytes
same as CD11a-c but on leukocytes!!
CD19
B cell activation; forms a co-receptor complex with CD21 and CD81 that delivers signals that synergize with signals from B cell antigen receptor complex
on most B cells
CD20
role in B cell activation or regulation; Calcium ion channel
on B cells
CD21
receptor for complement fragment C3d; delivers activating signals in B cells; receptor for EBV
on mature B cells and follicular DCs
CD25
binds IL-2 and promotes responses to low concentrations of IL-2; is the IL-2 receptor alpha chain
on activated T and B cells and Tregs
IL-2 receptor
daclizumab inhibits it
CD28
T cell receptor for CD80(B7-1) and CD86(B7-2)
on T cells
CD34
cell-cell adhesion
on precursors of HSCs and endothelial cells in HEVs
CD40
binds to CD154(CD40-L); role in T cell-mediated activation of B cells, macrophages and DCs
on B cells, macrophages, DC and endothelial cells
CD45
tyrosine phosphatase that regulates T and B cell activation
on hematopoietic cells
CD56
NK cell marker
CD62L
leukocyte-endothelial adhesion; homing of naive T cells to peripherial lymph nodes
on APCs
CD95
binds Fas Ligand; delivers signals leading to apoptotic death
on lots of cells
CD154
activates B cells, macrophages and endothelial cells; ligand for CD40
on activated CD4+ T cells
CD2
T cell activation; CTL and NK cell mediated lysis
something with RBCs - not sure
CD16
NK cell marker - binds Fc region of infected cells
