CD Markers

Question 1

CD34

Answer 1

Function: Cell-to-cell adhesion

Cell: Hematopoietic progenitor cells

Question 2

CD45

Answer 2

Function: Plays a key role in B cell and T cell signalling

Cell: Hematopoietic cells (all
leukocytes)

Question 3

CD3

Answer 3

Function: Identifies all T cells, T cell activation

Cell: All T cells

Question 4

CD7

Answer 4

Function: Lymphoid lineage marker

Cell: Pluripotent stem cells

Question 5

CD14

Answer 5

Function: LPS binding protein receptor/binds LPS binding protein and apoptotic cells

Cells: Monocytes/macrophages

Question 6

CD15

Answer 6

Function: Adhesion

Cell: Granulocytes(neutrophils, eosinophils, monocytes)

Question 7

CD16

Answer 7

Function: Fc receptor of Ig: promotes phagocytosis and
ADCC

Cell: NK cells/macrophages

Question 8

CD18

Answer 8

Function: Adhesion molecule

Cell: Leukocytes

Question 9

CD19

Answer 9

Function: Identifies B cells; role in B cell activation

Cell: Most B lymphocytes

Question 10

CD35

Answer 10

Function: Complement receptor

Cell: Leukocytes, erythrocytes

Question 11

CD40

Answer 11

Function: B cell and APC activation

Cell: B cells, APCs (macrophages, dendritic cells, endothelial cells)

Question 12

CD59

Answer 12

Function: Binds C9 & inhibits complement MAC formation Also known as MAC-IP (MAC inhibitor protein) or protection

Cell: Many

Question 13

CD61

Answer 13

Function: Adhesion, binds vitronectin and fibronectin

Cell: Thrombocytes

Question 14

CD62

Answer 14

Function: Adhesion molecule

Cell: Leukocytes, endothelial cells

Question 15

CD80

Answer 15

Function: Co-stimulator for T cell activation

Cell: Activated B cells, macrophages and dendritic cells

Question 16

CD4

Answer 16

Function: Identifies T helper cells of all subsets/binds MHC II

Cell: T helper cells

Question 17

CD8

Answer 17

Function: Identifies cytotoxic T cells/binds MHC I

Cell: Cytotoxic T cells

Question 18

CD25

Answer 18

Function: Induces activation and proliferation, IL-2rα chain: high-affinity IL-2 receptor

Cell: Activated B cells, T cells & constitutively on Treg cells, macrophages

Question 19

CD28

Answer 19

Function: Signal 2 for T cell activation; Receptor for B7
molecules – ligation is necessary to activate T cells

Cell: T cells

Question 20

CD40L

Answer 20

Function: Ligand for CD40; provides a signal to B cells to class switch

Cell: T cells

Question 21

CD45RO

Answer 21

Function: Identifies memory cells

Cell: Memory T cells

Question 22

CTLA-4

Answer 22

Function: Inhibitory receptor to end the IR; induces energy

Cell: T cells

Question 23

PD-1

Answer 23

Function: Inhibitory receptor indicative of cell exhaustion

Cell: T cells (CD8)

Question 24

FasL

Answer 24

Function: Induces apoptosis when binds to Fas on other cells

Cell: Cytotoxic T cells, NK cells

Question 25

CD20

Answer 25

Function: Identifies B cells, potential role in activation;
the target for many immunosuppressive therapies

Cell: B cells

Question 26

CD21

Answer 26

Function: C3d complement receptor; B cell activation

Cell: B cells

Question 27

CD40

Answer 27

Function: Stimulation of B cell isotype switching

Cell: B cell

Question 28

B7.1 or B7.2
(CD80/86)

Answer 28

Function: Signal 2 for T cell activation; provides ligation of CD28 on T cell for activation of T cell

Cell: B cells

Question 29

CD2

Answer 29

Function: Adhesion molecule for T cell activation

Cell: T cells, NK cells

Question 30

CD14

Answer 30

Function: LPS binding protein receptor

Cell: Monocytes/macrophages

Question 31

CD11b

Answer 31

Function: C3b complement receptor

Cell: Monocytes/macrophages/NK cells

Question 32

CD16 (FcγRIII)

Answer 32

Function: Phagocytosis and ADCC

Cell: macrophages/NK cells/neutrophils

Question 33

B7.1 or B7.2
(CD80/86)

Answer 33

Function: Signal 2 for T cell activation; ligates CD 28 on T cell

Cell: Monocytes/macrophages/dendritic
cells

Question 34

CD56

Answer 34

Function: Adhesion molecule

Cell: NK cells