CCR5 delta 32 Flashcards
1
Q
Macromolecule
A
CC Chemokine receptor 5 (CCR5); 32 base pair deletion in the coding region. Results in non-functional protein.
2
Q
Organelle
A
Protein receptor doesn’t reach cell surface.
3
Q
Cell
A
CCR5 receptor is missing. HIV-1 entry is impaired in homozygotes because of missing co-receptor.
4
Q
Organ/Organ Systems
A
HIV can’t infect cells; no subsequent death of T cells
5
Q
Organism
A
Homozygotes immune to HIV subtype.
6
Q
Population
A
Higher prevalence of this mutation in N. European descent. Still searching for selection pressure.
