CC - Plasma proteins Flashcards
familiarize with the groups of globulins and their functions
Gamma globulins (6)
- IgG
- IgA
- IgM
- IgD.
- IgE
- some CRP: NEGATIVE ACUTE PHASE REACTANTS=Albumin & Trasnferrin
Beta Globulins (7)
- Pre-Beta Lipoproteins
- Beta-Lipoproteins
- Transferrin
- Hemopexin
- Beta2-microglobulin
- Complement proteins
- C-reactive proteins
Alpha2-Globulins (3)
- Ceruloplasmin
- Haptoglobin
- Alpha2-macroglobulin
Alpha1-Globulins(7)
- Alpha1-antitrypsin
- Alpha1-antichymotrypsin
- Alpha-fetoprotein (AFP)
- Alpha1-acid glycoprotein
- Gc-globulin
- Thyroxine binding globulin
- Alpha-lipoproteins
Globulins (4)
Alpha1
Alpha2
Beta
Gamma
measurement of Globulins
Globulins = Total Protein - Albumin
marker for malnutrition
Pre-albumin / Transthyretin
landmark to confirm if specimen is really CSF
Pre-albumin / Transthyretin
Transfers T4 and retinol (vit. A)
Pre-albumin / Transthyretin
HIGH values of Pre-albumin
Alcoholism
Renal failure
Steroids
most abundant protein
Albumin
HIGH values of Albumin
Cystic fibrosis
normal value of Albumin
3.0 to 5.0 g/dL
osmotic pressure maintenace
Albumin
in which group is albumin related?
APR or NAPR
Negative Acute Phase Reactant
prevents tissue self destruction
A1-antitrypsin
aka alpha1-x
Alpha1-antichymotrypsin
Alpha1-antichymotrypsin binds with
PSA
protease inhibitor
A1-antitrypsin
associated with hepatic and gonodal carcinomas
Alpha-Feto protein (AFP)
LOW values of A1-antitrypsin is seen in
Emphysema
Juvenile cirrhosis
correlated with acute myocardial infarction and Alzheimer’s disease
Alpha1-antichymotrypsin
HIGH values of Alpha-Feto protein (AFP) is seen in
Twins
neural tube defects
HDN
LOW values of Alpha-Feto protein (AFP) is seen in
Down Syndrome Trisomy 18 (Edward's syndrome)
aka Orosomucoid
Alpha1-acid glycoprotein
vitamin D and actin affinity
Gc-globulin
binds thyroid hormones
Thyroxine binding globulin (TBG)
HDL / good cholesterol
Alpha-Lipoproteins
vitamin D transporter
Gc-globulin
carries progesterone
Alpha1-acid glycoprotein
aids in diagnosis of neonatal bacterial infections
Alpha1-acid glycoprotein
copper transporter
Ceruloplasmin
transports FREE HEMOGLOBIN
Haptoglobin
LOW values of Ceruloplasmin is seen in
Wilson’s disease(Kayser-fleisher rings),
Menke’s Kinky Hair syndrome
useful for evaluating intravascular hemolysis esp in HTR and HDN
Haptoglobin
alpha2-globulin that has enzymatic activity
Ceruloplasmin
LOW levels of Haptoglobin is seen in
Hemolysis
Hemoglobinuria
largest, major non immunoglobulin and not excreted in kidneys
(AMG) Alpha2-Macroglobulin
10x elevation in Nephrotic syndrome
(AMG) Alpha2-Macroglobulin
Pre-Beta-Lipoproteins
VLDL
TAG
Beta-Lipoproteins
LDL
Bad cholesterol
aka siderophilin
Transferrin
binds to heme
Hemopexin
light chain component of HLA
B2-Microglobulin
for immune response
Complement proteins
major B2 fraction component
Transferrin
HIGH levels of Transferrin
IDA (Iron Deficiency Anemia)
indicator of early hemolysis
Hemopexin
present in nucleated cells
B2-microglobulin
B2-microglobulin is needed in ____ production
CD8
in which group is transferrin related?
APR or NAPR
Negative acute phase reactant
dialysis associatedamyloidosis
B2-microglobulin
prevents iron loss
Transferrin
LOW levels of Complement proteins is seen in
Disseminated intravascular coagulation (DIC)
Hemolytic anemia
malnutrition
HIGH levels of B2-microglobulin
SLE RA MM HIV Renal failure
determines iron-carrying capacity of blood
Transferrin
promotes phagocytosis
CRP
most abundant gamma globulin
IgG
SECONDARY IMMUNE RESPONSE
IgG
useful cardiac marker
CRP
globulin for allergy anaphylaxis
IgE
globulin in mucous secretions
IgA
present in surface of B cells
IgD
GLOBULIN that is first to appear
IgM
Primary immune response
IgM
