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MUST KNOWS -Mam KATH LANGREO > CC - Plasma proteins > Flashcards

CC - Plasma proteins Flashcards

familiarize with the groups of globulins and their functions

1
Q

Gamma globulins (6)

A
  1. IgG
  2. IgA
  3. IgM
  4. IgD.
  5. IgE
  6. some CRP: NEGATIVE ACUTE PHASE REACTANTS=Albumin & Trasnferrin
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2
Q

Beta Globulins (7)

A
  1. Pre-Beta Lipoproteins
  2. Beta-Lipoproteins
  3. Transferrin
  4. Hemopexin
  5. Beta2-microglobulin
  6. Complement proteins
  7. C-reactive proteins
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3
Q

Alpha2-Globulins (3)

A
  1. Ceruloplasmin
  2. Haptoglobin
  3. Alpha2-macroglobulin
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4
Q

Alpha1-Globulins(7)

A
  1. Alpha1-antitrypsin
  2. Alpha1-antichymotrypsin
  3. Alpha-fetoprotein (AFP)
  4. Alpha1-acid glycoprotein
  5. Gc-globulin
  6. Thyroxine binding globulin
  7. Alpha-lipoproteins
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5
Q

Globulins (4)

A

Alpha1
Alpha2
Beta
Gamma

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6
Q

measurement of Globulins

A

Globulins = Total Protein - Albumin

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7
Q

marker for malnutrition

A

Pre-albumin / Transthyretin

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8
Q

landmark to confirm if specimen is really CSF

A

Pre-albumin / Transthyretin

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9
Q

Transfers T4 and retinol (vit. A)

A

Pre-albumin / Transthyretin

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10
Q

HIGH values of Pre-albumin

A

Alcoholism
Renal failure
Steroids

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11
Q

most abundant protein

A

Albumin

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12
Q

HIGH values of Albumin

A

Cystic fibrosis

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13
Q

normal value of Albumin

A

3.0 to 5.0 g/dL

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14
Q

osmotic pressure maintenace

A

Albumin

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15
Q

in which group is albumin related?

APR or NAPR

A

Negative Acute Phase Reactant

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16
Q

prevents tissue self destruction

A

A1-antitrypsin

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17
Q

aka alpha1-x

A

Alpha1-antichymotrypsin

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18
Q

Alpha1-antichymotrypsin binds with

A

PSA

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19
Q

protease inhibitor

A

A1-antitrypsin

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20
Q

associated with hepatic and gonodal carcinomas

A

Alpha-Feto protein (AFP)

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21
Q

LOW values of A1-antitrypsin is seen in

A

Emphysema

Juvenile cirrhosis

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22
Q

correlated with acute myocardial infarction and Alzheimer’s disease

A

Alpha1-antichymotrypsin

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23
Q

HIGH values of Alpha-Feto protein (AFP) is seen in

A

Twins
neural tube defects
HDN

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24
Q

LOW values of Alpha-Feto protein (AFP) is seen in

A 
Down Syndrome
Trisomy 18 (Edward's syndrome)
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25
Q

aka Orosomucoid

A

Alpha1-acid glycoprotein

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26
Q

vitamin D and actin affinity

A

Gc-globulin

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27
Q

binds thyroid hormones

A

Thyroxine binding globulin (TBG)

28
Q

HDL / good cholesterol

A

Alpha-Lipoproteins

29
Q

vitamin D transporter

A

Gc-globulin

30
Q

carries progesterone

A

Alpha1-acid glycoprotein

31
Q

aids in diagnosis of neonatal bacterial infections

A

Alpha1-acid glycoprotein

32
Q

copper transporter

A

Ceruloplasmin

33
Q

transports FREE HEMOGLOBIN

A

Haptoglobin

34
Q

LOW values of Ceruloplasmin is seen in

A

Wilson’s disease(Kayser-fleisher rings),

Menke’s Kinky Hair syndrome

35
Q

useful for evaluating intravascular hemolysis esp in HTR and HDN

A

Haptoglobin

36
Q

alpha2-globulin that has enzymatic activity

A

Ceruloplasmin

37
Q

LOW levels of Haptoglobin is seen in

A

Hemolysis

Hemoglobinuria

38
Q

largest, major non immunoglobulin and not excreted in kidneys

A

(AMG) Alpha2-Macroglobulin

39
Q

10x elevation in Nephrotic syndrome

A

(AMG) Alpha2-Macroglobulin

40
Q

Pre-Beta-Lipoproteins

A

VLDL

TAG

41
Q

Beta-Lipoproteins

A

LDL

Bad cholesterol

42
Q

aka siderophilin

A

Transferrin

43
Q

binds to heme

A

Hemopexin

44
Q

light chain component of HLA

A

B2-Microglobulin

45
Q

for immune response

A

Complement proteins

46
Q

major B2 fraction component

A

Transferrin

47
Q

HIGH levels of Transferrin

A

IDA (Iron Deficiency Anemia)

48
Q

indicator of early hemolysis

A

Hemopexin

49
Q

present in nucleated cells

A

B2-microglobulin

50
Q

B2-microglobulin is needed in ____ production

A

CD8

51
Q

in which group is transferrin related?

APR or NAPR

A

Negative acute phase reactant

52
Q

dialysis associatedamyloidosis

A

B2-microglobulin

53
Q

prevents iron loss

A

Transferrin

54
Q

LOW levels of Complement proteins is seen in

A

Disseminated intravascular coagulation (DIC)
Hemolytic anemia
malnutrition

55
Q

HIGH levels of B2-microglobulin

A 
SLE
RA
MM
HIV
Renal failure
56
Q

determines iron-carrying capacity of blood

A

Transferrin

57
Q

promotes phagocytosis

A

CRP

58
Q

most abundant gamma globulin

A

IgG

59
Q

SECONDARY IMMUNE RESPONSE

A

IgG

60
Q

useful cardiac marker

A

CRP

61
Q

globulin for allergy anaphylaxis

A

IgE

62
Q

globulin in mucous secretions

A

IgA

63
Q

present in surface of B cells

A

IgD

64
Q

GLOBULIN that is first to appear

A

IgM

65
Q

Primary immune response

A

IgM

MUST KNOWS -Mam KATH LANGREO (2 decks)

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