CBC anemia Flashcards
MCV
first thing that you should look at if they are anemic
MCV is measure of average red cell size
80-100
Microcytic
= Decreased MCV
Low 60 –80 fL
Markedly low < 60 fL
Fe deficiency, thalassemia, chronic disease, sideroblastic anemia
normocytic
Normal MCV 80-100 fL
acute blood loss, infection, bone marrow suppression, renal insufficiency, endocrine dysfxn
Macrocytic
= High MCV > 100 fL
ETOH abuse, folate, B12 defects, Reticulocytosis (hemolytic anemia)
MCHC
mean cell Hb concentration
second measurement
surrogate measure of Hb concentration w/in avg sized RBC
value for chromaticity
Reticulocyte count
has residual DNA that stains Methylene blue
rate of production and release of red cells by the marrow into the peripheral blood.
adult-.5-1.5%
Peds: 3-7%
common cause of reticulocytosis
Acute blood loss or hemorrhage
Acute hemolysis
Hemolytic anemia
Response to therapy (Fe or other
nutritional correction of deficiency
Iron deficiency anemia
Microcytic anemia+ low serum ferritin + low serum Fe + high serum binding capacity (TIBC, sTfR)
Anemia of chornic disease
High ferritin, low TIBC, low serum Fe, high sTfR
Coombs test
IgG coating RBCs
positive in hemolytic anemia
Haptoglobin
free Hb binding binding protein
low in hemolytic anemia
Hb electrophoresis
presence of abnormal Hbs
+Thalassemia (Hgb A2 and F)
+Sickle cell (Hgb S (sickle cell)
Bilirubin
RBC destruction
total and UC are elevated in hemolytic anemia
RDW
variation in sizes w/in a population of RBC
High in hemolytic anemia
Peripheral smear
Morphology
Fragmented RBCs spherocytes, elliptocytes, nRBCs, dacrocytes
