CBC Flashcards
WBC
(10^9/L)
Male and Female = 4.0 – 11.1
RBC
(10^12/L)
Male = 4.7 – 6.0
Female = 4.1 – 5.6
HGB
(g/dL)
Male = 14.3 – 18.1
Female = 12.1 – 16.3
HCT
% = V of RBC in whole blood
= RBCxMCV = 3 x HGB
Male = 39.2 – 50.2
Female = 35.7 – 46.7
MCV
(fL)
MCV =mean RBC size =HCT/RBC
Male and Female = 80.0 – 100.0
MCH
(pg) quantity hgb in 1 RBC
Parallels MCV = HGB/RBC
Male and Female = 27.5 – 35.1
MCHC
(g/dL) = avg [C] of hgb in 1 RBC
= HGB/HCT = MCH/MCV
Male and Female = 32.0 – 36.0
RDW CV
Male and Female = 11.7 – 14.2
RDW SD
Male and Female = 37.1 – 48.8
PLT
(10^9/L)
Male and Female = 150 – 400
MPV
(fL)
Male and Female = 9.6 – 12.8
NE%
Male and Female = 39.7 – 72.1
NE#
(10^9/L)
Male and Female = 1.8 – 6.6
LY%
Male and Female = 20.0 – 50.0
LY#
(10^9/L)
Male and Female = 1.0 – 4.8
MO%
Male and Female = 2.0 – 11.0
MO#
(10^9/L)
Male and Female = 0.2 – 0.9
EO%
Male and Female = 0.0 – 6.0
EO#
(10^9/L)
Male and Female = 0.0 – 0.4
BA%
Male and Female = 0.0 – 2.0
BA#
(10^9/L)
Male and Female = 0.0 – 0.2
Male and Female have same values
WBC and WBC Differential, MCV, MCH, MCHC, RDW CV and SD, PLT, MPV
RBC Morphology and Properties
Circular biconcave disc-shaped Size: 6.7–7.7µm, mean 7.5µm Lack of nuclei, Lack of Mitochondria Anaerobic metabolism Depends on GSH/phosphogluconate/NADPH for clearance of free radicals Eosinophilic cytoplasm Central area of pallor, <1/3 of diameter
Anemia
Decreased RBC, HGB, HCT
and Increased RDW
- due to blood loss, peripheral destruction, or ineffective erythropoiesis in the bone marrow
Erythrocytosis/Polycythemia
Increased RBC, HGB, HCT
- due to reactive changes (smoking, renal cell carcinoma), or primary marrow neoplasm (polycythemia vera)
HCT abnormal values
Decreased due to anemia or fluid overload
Increased due to erythrocytosis/polycythemia or dehydration
MCV abnormal values
Low MCV: Microcytosis, iron deficiency anemia or thalassemia
High MCV: Macrocytosis, megaloblastic anemia
MCH abnormal values
Low MCH: Hypochromatic, iron deficiency anemia
High MCH: Hyperchromatic, megaloblastic anemia
MCHC abnormal values
Decreased in moderate to severe microcytic anemia
Increased in hereditary spherocytosis, HbS, HbC
Normal in macrocytic anemias
RDW abnormal values
Increased in anemia and disease with RBC destruction (i.e. schistocytosis)
Fe Deficiency Anemia
decreased RBC, HGB, HCT< MCV, MCH, MCHC
increased RDW
Bite Cells
Bite-like detect due removal of Heinz body (Denatured/oxidized hemoglobin attached to the inner cell membrane) in spleen
Associated with G6PD deficiency
Target Cells
Central hemoglobin, target shape
Associated with Thalassemia, hemoglobin C, iron deficiency, liver disease
Basophilic Stippling
Morphology: evenly dispersed fine blue granules
Content: aggregated ribosomes (rRNA)
Causes:
Lead poisoning, porphyria, pyrimidine 5’ nucleotidase deficiency
Hemoglobinopathies, thalassemia
Myelodysplasia, sideroblastic anemia
Infection
Howell-Jolly bodies
Morphology: single, dense, blue dot Content: nuclear DNA remnant Causes: Post-splenectomy Functional asplenia Megaloblastic anemia Myelodysplasia
