CAW Basics Flashcards

1
Q

3 types of mesh

A

Synthetic, Biologics, Bioresorbable

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2
Q

Biological Mesh Response in Body

A
Cells penetrate implant pores
Enzymatic Degradation
Angiogenesis
Cells and collagen proliferate
Natural tissue completely replaces graph
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3
Q

Wound Healing Race

A

Winning: wound heals before graft remodels

Not winning: graft degrades before wound heals

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4
Q

Why wouldn’t a surgeon want to use a synthetic graft?

A

Infection or contamination, synthetic mesh is permanent

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5
Q

Why use a biologic?

A

Graft goes away, less foreign body response

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6
Q

What is XenMatrix mesh madeout of

A

non-cross linked porcine dermis

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7
Q

XenMatrix’s open _______ strucure allows for early remodeling

A

collagen

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8
Q

Two antibiotics on Xenmatrix AB

A

Rifampin and Monocylin

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9
Q

Which two bacteria is XenMatrix known to protect against?

A

MRSA and E.Coli

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10
Q

How long does XenMatrix antibacterial coating last?

A

7-14 days

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11
Q

Polymer that binds antibacterial coating to Xenmatrix?

A

Tyrosine

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12
Q

Rifampin

A

kills bacteria

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13
Q

Minocyclin

A

stops replication of bacteria

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14
Q

Zone of Inhibition

A

We have a larger zone of inhibition than our competitors

Zone of inhibition is where the mesh is capable of inhibiting bacteria colonization

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15
Q

Repair strength of XenMatrix AB is ____ times stronger than the natural abdominal wall

A

3

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16
Q

Heniford Study General Tkae away

A

Came out that XenMatrix was the most expensive and we had the highest rate of infection

17
Q

XenMatrix AB detectable drug concentration

A

will not result in detectable systemic concentrations of Rifampin or Minocycline

18
Q

What is the likelihood of antibiotic resistance with XenMatrix AB?

A

clinical studies have shown that it is unlikely that a bacterial strain will become resistant to both drugs at the same time

19
Q

What is Phasix made of

A

poly 4 hydroxybutyrate

20
Q

How does Phasix degrade?

A

hydrolysis

21
Q

How long does it take for Phasix to be resorbed?

A

12-18 months

22
Q

What happens when Phasix comes in contact with bacteria?

A

Nothing. Phasix is broken down by hydrolysis

23
Q

Phasix mesh has an open _____ structure that allows for _____ and ______

A

monofilament

early tissue ingrowth and vascularization

24
Q

XenMatrix ____ kills bacteria and Phasix _____ kills bacteria

A

actively

passively

25
Q

Matthews study for Phsaix

A

as mesh strength decreases over time, new healthy abdominal wall strength increases

26
Q

Phasix ST difference from Phasix

A

has the sepra technology which works as barrier for intraabdominal placement

27
Q

What is Sepra Technology made of

A

PEG
HA
CMC

28
Q

Phasix ST can be placed in which two planes?

A

intrabdominal or preperitoneal

29
Q

Phasix ST comes in home many sizes?

A

12

30
Q

How long does it take for the hydrogel barrier to resorb?

A

30 days

31
Q

How does the Sepra Technology stay on the mesh?

A

PGA fibers weave the ST into the mesh