CAW Basics Flashcards
3 types of mesh
Synthetic, Biologics, Bioresorbable
Biological Mesh Response in Body
Cells penetrate implant pores Enzymatic Degradation Angiogenesis Cells and collagen proliferate Natural tissue completely replaces graph
Wound Healing Race
Winning: wound heals before graft remodels
Not winning: graft degrades before wound heals
Why wouldn’t a surgeon want to use a synthetic graft?
Infection or contamination, synthetic mesh is permanent
Why use a biologic?
Graft goes away, less foreign body response
What is XenMatrix mesh madeout of
non-cross linked porcine dermis
XenMatrix’s open _______ strucure allows for early remodeling
collagen
Two antibiotics on Xenmatrix AB
Rifampin and Monocylin
Which two bacteria is XenMatrix known to protect against?
MRSA and E.Coli
How long does XenMatrix antibacterial coating last?
7-14 days
Polymer that binds antibacterial coating to Xenmatrix?
Tyrosine
Rifampin
kills bacteria
Minocyclin
stops replication of bacteria
Zone of Inhibition
We have a larger zone of inhibition than our competitors
Zone of inhibition is where the mesh is capable of inhibiting bacteria colonization
Repair strength of XenMatrix AB is ____ times stronger than the natural abdominal wall
3
Heniford Study General Tkae away
Came out that XenMatrix was the most expensive and we had the highest rate of infection
XenMatrix AB detectable drug concentration
will not result in detectable systemic concentrations of Rifampin or Minocycline
What is the likelihood of antibiotic resistance with XenMatrix AB?
clinical studies have shown that it is unlikely that a bacterial strain will become resistant to both drugs at the same time
What is Phasix made of
poly 4 hydroxybutyrate
How does Phasix degrade?
hydrolysis
How long does it take for Phasix to be resorbed?
12-18 months
What happens when Phasix comes in contact with bacteria?
Nothing. Phasix is broken down by hydrolysis
Phasix mesh has an open _____ structure that allows for _____ and ______
monofilament
early tissue ingrowth and vascularization
XenMatrix ____ kills bacteria and Phasix _____ kills bacteria
actively
passively
Matthews study for Phsaix
as mesh strength decreases over time, new healthy abdominal wall strength increases
Phasix ST difference from Phasix
has the sepra technology which works as barrier for intraabdominal placement
What is Sepra Technology made of
PEG
HA
CMC
Phasix ST can be placed in which two planes?
intrabdominal or preperitoneal
Phasix ST comes in home many sizes?
12
How long does it take for the hydrogel barrier to resorb?
30 days
How does the Sepra Technology stay on the mesh?
PGA fibers weave the ST into the mesh
