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The Liver 2113 > Causes of Iiver disease > Flashcards

Causes of Iiver disease Flashcards

1
Q

What are the possible viral infections that can cause liver disease?

A

Hepatitis A-E

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2
Q

What is Hep A

A

Faecal contamination of food and drink

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3
Q

What is Hep B

A

Blood/blood contamination

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4
Q

What is Hep C

A

Blood/blood contamination

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5
Q

What is Hep D

A

Have to have Hep B to get Hep D, can be acute or chronic liver disease

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6
Q

What is Hep E

A

Faecal contamination of food or drink

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7
Q

What is othe single most significant cause of Liver disease in the wetern world?

A

Chronic use of Alcohol

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8
Q

What does the chronic use of alcohol leaf to?

A

Eventually leads to Cirrhosis. Fibrous tissue scarring increases resistance to blood flow from the Portal system resulting in portal hypertension (PHT)

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9
Q

What is the portal system?

A

The system of blood vessels consisting of the Hepatic Portal Vein and its capillary network.

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10
Q

What does the rate of progression and regression linked to?

A

Further/less alcohol consumption

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11
Q

What are the other causes of liver disease apart from alcohol consumption and viruses?

A

Non-alcoholic fatty liver disease (harmless) and Non-alcoholic Steatohepatitis (can lead to cirrhosis)

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12
Q

What is Non-alcoholic steatohepatitis?

A

A pathology similar to Alcohol liver disease. Fatty build up and inflammation which can lead to Cirrhosis

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13
Q

What is non-alcoholic Steatohepatitis associated with?

A

Recognised in conditions such as obeisity, diabetes and metabolic syndrome

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14
Q

What are the other less common causes of liver disease?

A

Cholestasis, Immune disorders, Vascular abnormalities, Metabolic Disorders, Genetic Disorders

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15
Q

What is Cholestasis?

A

the blockage of bile release (intra-hepatic and extra-hepatic i.e. caused by the liver or another organ like the pancreas)

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16
Q

What are the different types of drug related liver disease?

A

Type A- dose related, withdrawl of precipitating drug results in reversal e.g. paracetamol, tetracyclines, methotrexate
Type B - Idiosyncratic (unique for each individual, can’t be predicted and not dose related). Can be due to hypersensitivity or metabolic.

17
Q

What seems to have increased the rate of liver disease over the years?

A

The increase in price of Alcohol over the years has resulted in more people dinking stronger alcohol at home

18
Q

Appart from alcohol, what is another major issue involving liver disease?

A

Obeisity- The vast majority of the UK population who are obease have non-alcoholic related fatty liver disease

The Liver 2113 (7 decks)

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