Causes of Disease

Question 1

Overactivation of wound healing macrophages causes…

Answer 1

Fibrosis

Question 2

What causes chron’s disease?

Answer 2

Mutations to overstimulate NOD2 LRR resulting in overstimulation or lack of stimulation

Question 3

Is MyD88 K/O viable?

Answer 3

Mice KO produce no inflammatory cytokines IL-1beta, IL-6, TNFalpha

Question 4

How do dectin mutations cause fungal infections?

Answer 4

Promoter SNPs KO expression

Question 5

What is neutropenia?

Answer 5

Lack of neutrophils

Question 6

What can cause neutropenia?

Answer 6

Immune compromised patients from chemotherapy

Gene defects

Question 7

What is a symptom of neutropenia?

Answer 7

Immunocompromised
High mortality
Poor wound healing

Question 8

What cancer does neutrophilia cause?

Answer 8

AML

Question 9

What are AML neutrophils like?

Answer 9

Immature/non-functional

Question 10

What causes osteoarthritis?

Answer 10

Increase in pro inflammatory miRNA

Question 11

What can cause miRNA dysregulation?

Answer 11

Chronic low grade inflammation

Question 12

What causes gout?

Answer 12

Purines produce Uric acid crystals which induce macrophages and activate nlrps

Question 13

What syndrome can be caused by immunodeficiencies in the inflammasome?

Answer 13

Muckle wells syndrome

Question 14

What genetic basis does muckle wells syndrome have?

Answer 14

Hyperactive nlrp assembly leading to too much IL1