Catecholamine Synthesis Flashcards
1
Q
Effects of TH deficiency
A
General rigidity
Hypokinesia
Low CSF levels of NA and DA metabolites
2
Q
Effects of DBH deficiency
A
Orthostatic hypotension
Ptosis of the eyelids
Retrograde ejaculation
Elevated plasma DA
3
Q
Components of the NA storage vesicles
A
Neuropeptide Y
Encephalins
ATP
NA
DBH
Ascorbic acid
Chromogrannins
4
Q
How do glucocorticoids control the synthesis of AD in the adrenal medulla?
A
They influence the expression of the PNMT, which converts NE to DE.
5
Q
Components of LDC and SDC storage vesicles
A
LDC orresponds to chromaffin granules
SDC contains NE, ATP, and membrane-bound DBH
6
Q
VMAT2 is drive by…
A
pH and potential gradients that are established by an ATP-dependent proton translocase.