Catecholamine Synthesis Flashcards

1
Q

Effects of TH deficiency

A

General rigidity
Hypokinesia
Low CSF levels of NA and DA metabolites

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2
Q

Effects of DBH deficiency

A

Orthostatic hypotension
Ptosis of the eyelids
Retrograde ejaculation
Elevated plasma DA

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3
Q

Components of the NA storage vesicles

A

Neuropeptide Y
Encephalins
ATP
NA
DBH
Ascorbic acid
Chromogrannins

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4
Q

How do glucocorticoids control the synthesis of AD in the adrenal medulla?

A

They influence the expression of the PNMT, which converts NE to DE.

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5
Q

Components of LDC and SDC storage vesicles

A

LDC orresponds to chromaffin granules
SDC contains NE, ATP, and membrane-bound DBH

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6
Q

VMAT2 is drive by…

A

pH and potential gradients that are established by an ATP-dependent proton translocase.

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