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PHA314 > Adrenergic Drugs > Flashcards

Adrenergic Drugs Flashcards

1
Q

Direct acting adrenergic agonists

A

Epi
NE
Phenylephrine
Albuterol

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2
Q

Direct acting adrenergic agonists MOA

A

They bind to receptors to release NE

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3
Q

Direct acting adrenergic agonists

A

Tyramine
Amphetamine

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4
Q

Mixed acting adrenergic drugs

A

Ephedrine

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5
Q

Peculiarities of phenylephrine, ephedrine, and amphetamine

A

No catechol hydroxy group
Long half life
Not inactivated by COMT
Poor substrates for MAO
Lipid-soluble

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6
Q

Agonists and their preferred receptors

A

Epi - a1, a2, B1, B2
NE - a1, a2, B1
Isoprenaline - B1, B2

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7
Q

Dopamine 1 agonists

A

Dobutamine
Fenoldopam

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8
Q

MOA of indirect acting agonists

A
  • by releasing or displacing NA from sympathetic nerve varicosities,
  • by blocking the transport of NA into sympathetic neurons
  • by blocking the metabolizing enzymes, MAO
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9
Q

Indirect acting agonists that act by releasing or displacing NA from sympathetic nerve varicosities

A

Amphetamine, Tyramine

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10
Q

Indirect acting agonists that act by blocking the transport of NA into sympathetic neurons

A

Cocaine
Imipramine
Desipramine

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11
Q

Indirect acting agonists that act by blocking the metabolizing enzymes, MAO and COMT

A

MAO - Pargyline
COMT - Entacapone

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12
Q

Examples of MOA-A inhibitors

A

Phenelzine
Tranylcypromine

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13
Q

Examples of MOA-B inhibitors

A

Selegiline

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14
Q

Examples of COMT inhibitors

A

Tolcapone (long-acting)
Entacapone (short-acting)

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PHA314 (4 decks)

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