Catecholamine Receptors Flashcards

1
Q

D1 Receptors

A

Located in splanchnic arterioles

Causes vasodilation when agonized

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2
Q

D2 Receptors

A

Located in medulla and pituitary

Causes emesis in medulla (due to chemoreceptor trigger zone stimulation) and anxiety and fear in the midbrain-cortex

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3
Q

Alpha 1 Receptors

A

Located in pons, medulla, and blood vessels
Agonists in pons and medulla cause stimulation of RAS neurons to increase alertness and behavioral excitement
In blood vessels, causes vasoconstriction and splenic contraction leading to increased hematocrit

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4
Q

Alpha 2 receptors

A

Located in pons, medulla, spinal cord, blood vessels, pituitary, and pancreas
Causes decreased arousal in pons and medulla
Muscle relaxation and analgesia in spinal cord
Vasoconstriction hypertension and reflex bradycardia in high concentration in the blood vessels but all the opposite in low concentrations
And inhibits ADH (leads to diuresis and loss of water resorption) and insulin release in pituitary and pancreas

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5
Q

Opioid Receptor Cellular Actions

A

Diectly activate G-protein inwardly rectifying potassium channels (GIRK)
Directly inhibit voltage gated Ca channels and adenylyl cyclase
Indirectly activates calcium-activated big potassium channels (BK), phospholipase C, and mitogen activated protein kinase
Overall, causes neuronal hyperpolarization acting on Gprotein secondary messengers

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6
Q

Opioid Receptor Locations

A

Throughout CNS

Afferent nociceptive neurons and dorsal root ganglia

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7
Q

Opioid Effects

A

Analgesia on peropheral nociceptors, dorsal horn of spinal cord, and brain regions of medulla, pons, midbrain, and cortex
Sedation in most animals in brain receptors, euphoria in cats in small doses but excitation in high doses in cats and horses

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