Case Study: Anticoagulation Flashcards
What are the main uses of blood thinners?
Prevent thrombus formation in the venous circulation
What is prothrombin time used for?
DOACs
= blood test for thinning
What is INR used for?
Warfarin
What are the anticoagulants in the UK?
Warfarin
Apixaban
Rivaroxaban
Edoxaban
dabigatran
What do vitamin K antagonists do?
Inhibit the vitamin K dependent clotting factors
What are the vitamin K dependent clotting factors?
II
VII
IX
X
What is an example of a vitamin K antagonist?
Warfarin
What are the DOACs?
Apixaban
Edoxaban
Rivaroxaban
Dabigatran
What does Apixaban, Edoxaban + Rivaroxaban do?
Direct + reversible inhibitors of factor Xa
What does dabigatran do?
Reversible inhibitor of free thrombin
What are the risk factors of indication for DOACs?
Age >75 years
Hypertension
Diabetes
Symptomatic HF
What are the contraindications for DOACs?
Active bleeding
Acute stroke
GI bleeding
Intracranial bleeding
Family history
Which anticoagulant is there NOT a reversible agent for?
Edoxaban
What are the different monitoring requirements for Warfarin?
INR
TTR
Reassess suitability
Describe INR
Target range for indication
How often are INR done?
When newly on it
= every week
What is TTR?
Total time in range