case study Flashcards
particles with a diameter of …. or less have POOR flow properties
50um or less
Good angle of repose is…
25 degrees
angle of repose greater than … have poor flow
45 degrees
What can you add to reduce angle reduce of repose?
glidant
How can you measure Carr’s index?
bulk density or tapped density
how is Carr index related to number of pores?
the lower the Carr index, the more pores, the better the flow
As dose increases past …mg, compaction becomes an important factor
50mg
give an example of a polymorph
amorphous solids
the larger the Ka …
the more soluble
The larger the pKa…
the less soluble
contact angle is related to what concept?
wettability
what contact angle is good?
less than 90 degrees
give examples of wetting agents to reduce contact angle
SLS, tween, lethicin
What are the 2 types of flow?
plastic and pseudo plastic
What polymers are used in film coating?
PVP, PEG
What does hygroscopicity affect?
drying, flow and ease of compaction
What are soft gel capsules good for?
highly potent drugs, greater than dose of 100um
using liquids/co-solvents to aid solubility
If powder flow is uneven, what can it lead to?
trapped air
capping and lamination
excess fine powder
dust contamination risks to handlers
what are the good and bad values for Carr index?
good: below 15%
bad: between 26-31%
15-26 is aight
What is brittle fracture?
the solid doesn’t deform/isn’t plastic so can lead to capping so we need to add a binder such as PVP
how are salts and water absorption related?
salts absorb more water than the free acid/base
what should solubility value be above to be ‘good’?
above 10
