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medicine sem2 > case study > Flashcards

case study Flashcards

1
Q

particles with a diameter of …. or less have POOR flow properties

A

50um or less

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2
Q

Good angle of repose is…

A

25 degrees

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3
Q

angle of repose greater than … have poor flow

A

45 degrees

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4
Q

What can you add to reduce angle reduce of repose?

A

glidant

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5
Q

How can you measure Carr’s index?

A

bulk density or tapped density

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6
Q

how is Carr index related to number of pores?

A

the lower the Carr index, the more pores, the better the flow

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7
Q

As dose increases past …mg, compaction becomes an important factor

A

50mg

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8
Q

give an example of a polymorph

A

amorphous solids

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9
Q

the larger the Ka …

A

the more soluble

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10
Q

The larger the pKa…

A

the less soluble

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11
Q

contact angle is related to what concept?

A

wettability

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12
Q

what contact angle is good?

A

less than 90 degrees

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13
Q

give examples of wetting agents to reduce contact angle

A

SLS, tween, lethicin

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14
Q

What are the 2 types of flow?

A

plastic and pseudo plastic

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15
Q

What polymers are used in film coating?

A

PVP, PEG

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16
Q

What does hygroscopicity affect?

A

drying, flow and ease of compaction

17
Q

What are soft gel capsules good for?

A

highly potent drugs, greater than dose of 100um

using liquids/co-solvents to aid solubility

18
Q

If powder flow is uneven, what can it lead to?

A

trapped air
capping and lamination
excess fine powder
dust contamination risks to handlers

19
Q

what are the good and bad values for Carr index?

A

good: below 15%
bad: between 26-31%
15-26 is aight

20
Q

What is brittle fracture?

A

the solid doesn’t deform/isn’t plastic so can lead to capping so we need to add a binder such as PVP

21
Q

how are salts and water absorption related?

A

salts absorb more water than the free acid/base

22
Q

what should solubility value be above to be ‘good’?

A

above 10

medicine sem2 (7 decks)

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