Case Presentation

Question 1

What is the first line treatment for hepatitis C?

Answer 1

Interferon

Ribavirin

Question 2

What are the hepatic manifestations of alcohol overconsumption?

Answer 2

Fatty liver

Alcoholic Hepatitis

Hepatic fibrosis or cirrhosis

Question 3

What is the pathophysiology of fatty liver?

Answer 3

NAD+ decrease → decrease gluconeogenesis → increase fatty acids

Fatty deposits in space of Disse

Question 4

What is the pathophysiology of alcoholic hepatitis?

Answer 4

Alcohol consumption → increased acetaldehyde production → toxic effects of acetaldehyde

Question 5

What are some signs and symptoms of alcoholic hepatitis?

Answer 5

Change in appetite, tiredness and weakness, fever, hepatomegaly, RUQ pain, jaundice, N+V, WL

Question 6

If liver inflammation → fibrosis that results in necrosis and scarring, what is this called?

Answer 6

Hepatic Fibrosis/Cirrhosis

Question 7

What signs and symptoms are assoicated with Hepatic Fibrosis/Cirrhosis?

Answer 7

Same as Alcoholic hepatitis plus:

Oedema/ascites,

bruising/bleeding, malaena,

portal hypertension → varices,

hepatic encephalopathy (liver can’t remove toxins → brain),

liver failure