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Neuro Block 2 > Case Based Learning; GBM > Flashcards

Case Based Learning; GBM Flashcards

1
Q

Temozolomide

A

Anti-neoplastic

DNA- alkylation of O6, N7 Guanine

Best BBB penetration!!

CCNS

Used to treat GBM

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2
Q

Carmustine

A

Anti-neoplastic (alkylating agent)

Alkylation/Cross-linking DNA/RNA

Crosses BBB

CCNS

Short half-life. IV, implant

Side Effects: Bone marrow suppression, GI, Liver w/ high doses

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3
Q

Vincristine

A

anti-neoplastic

inhibits microtubule formation

Best antimitotic for crossing BBB… but is poor overall

CCNS

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4
Q

What drug is used in addition to anti-mitotics for reducing cerebral edema?

A

dexamethasone

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5
Q

What are the two anti-neoplastics we learned this week that alkylate DNA?

A
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Neuro Block 2 (10 decks)

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